New ribozyme can make #RNA molecules accessible for #clickchemistry in living cells https://phys.org/news/2023-09-ribozyme-rna-molecules-accessible-click.html

Damn this is hot - imagine the possibilities for single sell #RNAseq @nanopore
#sequencing

Sahil Kamboj from our collaborator Ambroise Lambert’s lab showed us how @roylelab’s favourite tools can be used to develop probes to tackle key questions for understanding the #tumour microenvironment. The #clem + endocytosis hot-wiring in spheroids were amazing 🤩

It’s been a joy to follow my DTP colleague + friend Will Scott’s journey on using genetic code expansion + #clickchemistry to develop new tools for imaging #actin. I’m looking forward to seeing this probe in cells soon! #cellbiology

A new method to detect native #glycoRNA from Ryan Flynn's lab.

#RNA #mRNA #ClickChemistry

https://www.biorxiv.org/content/10.1101/2023.02.26.530106v1?med=mas

Nanotech Enzyme Process Boosts T-Cell Cancer Therapies

A #bioengineering team devised techniques for feasibly adding cancer-killing #enzymes to engineered #immune cells that in lab mice kill solid #tumor and blood #cancer cells.

https://sciencebusiness.technewslit.com/?p=44317

#News #Science #Engineering #Biotechnology #Chemistry #ClickChemistry #Nanotechnology #Cytokines #Preclinical #University

Sorry to the reviewer who chose an arbitrary out-of-subject field (chemistry) while trying to argue against the significance of my sister's paper. You couldn't have known we were related, but I got to squee at her about click chemistry for 10 minutes to describe why tool development is important for future discovery.

#SorryNotSorry #Science #ClickChemistry #ChemicalBiology #ChemiVerse

"...biorthogonal (chemistry) means not interacting with biology..."

#NobelPrize #CarolynBertozzi #BioorthogonalChemistry #ClickChemistry #Chemotherapy #DrugDesign #Biochemistry

A Nobel Prize For Chemistry Work ‘Totally Separate From Biology’ https://www.sciencefriday.com/segments/nobel-prize-chemistry-biology/

What a great, accessible summary of the work awarded the 2022 Nobel Prize in Chemistry (@CarolynBertozzi@twitter.com, Meldal, Sharpless) by @TheZeglisLab@twitter.com and @LewisLabMSKCC@twitter.com!

#clickchemistry

https://www.nejm.org/doi/pdf/10.1056/NEJMcibr2213596?articleTools=true

Great piece by the very talented
Claire O'Connell out on The Irish Times @irishtimes celebrating the #ChemNobel to #ClickChemistry and #BioOrthogonalChemistry with some enthusiastic feedback from me and Andrew Kellet

@bertozzi I hope you'll like it 😊👏👏👏

https://www.irishtimes.com/science/2022/12/01/click-and-collect-the-nobel-prize-in-chemistry/

#glycotime #chemiverse #chemistry #Nobel

This 2021 article was shared by RSC chemical biology for #FluorescenceFriday:
https://pubs.rsc.org/en/content/articlelanding/2021/cb/d1cb00002k

Tbh I was not aware of click-based amplification techniques and this paper hasn't been cited yet or gained much attention otherwise.

The research this was based on has been applied only to nucleic acid imaging:
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201700209

So the question is has anyone tried this? Does it work and is it useful?

#clickchemistry #bioimaging #bioorthogonal

This 2021 article was shared by RSC chemical biology for #FluorescenceFriday

https://pubs.rsc.org/en/content/articlelanding/2021/cb/d1cb00002k

Tbh I was not aware of click-based amplification techniques and this paper hasn't been cited yet or gained much attention otherwise.

The research this was based on has been applied only to nucleic acid imaging:
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201700209

So the question is has anyone tried this? Does it work and is it useful?

#clickchemistry #bioimaging #bioorthogonal

This 2021 article was shared by RSC chemical biology for #FluorescenceFriday

https://pubs.rsc.org/en/content/articlelanding/2021/cb/d1cb00002k

Tbh I was not aware of click-based amplification techniques and this paper hasn't been cited yet or gained much attention otherwise.

The research this was based on has been applied only to nucleic acid imaging:
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201700209

So the question is has anyone tried this? Does it work and is it useful?

#clickchemistry #bioimaging #bioorthogonal

ACS Chem Biol put together a special issue on #bioorthogonal and #clickchemistry, great selection of articles that touch upon every biomolecule type with far-ranging applications in biology and medicine. Well done!

https://pubs.acs.org/page/acbcct/vi/click-bioorthogonal-chemistry

Hi everyone! I'm @basktastic on Twitter but am trying out my real name here. My #chembio #cellbio #lipidtime lab at Cornell develops tools for imaging and editing the lipidome, drawing on #bioorthogonal chemistry, #clickchemistry, #chemoproteomics, #optogenetics, #directedevolution, and more. https://baskin.wicmb.cornell.edu

Hi everyone! I'm @basktastic on Twitter but am trying out my real name here. My #chembio #cellbio #lipidtime lab at Cornell develops tools for imaging and editing the lipidome, drawing on #bioorthogonal chemistry, #clickchemistry, #chemoproteomics, #optogenetics, #directedevolution, and more. https://baskin.wicmb.cornell.edu