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#IDMastodon #Immunology Most #Monoclonalantibodies against the RBD that are potent against the ancestral virus were prioritized for #clinicaldevelopment . However, most of these antibodies lost efficacy because of amino acid changes in #SARSCoV2 variants that possibly resulted from immune pressure.
📌 https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01214-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124721012146%3Fshowall%3Dtrue