#IDMastodon #Publichealth #pediatrics @jamanetworkopen in this #clinicalreview of 42 studies including 102 984 youths .The incidence rates of #type1diabetes and DKA at diabetes onset in children & adolescents were higher after the start of the #COVID19 pandemic than before the pandemic. Increased resources and support may be needed for the growing number of children and adolescents with #diabetes.
📌 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2806712

#IDMastodon #viralimmunology #COVID19 #Clinicalreview @frontimmunol a comprehensive review on #SarsCoV2 human responses including a detailed summary of the current state of the host immune response
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1195871/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit

#IDMastodon #Immunopharmacology #Drugdevelopment #Microbiology #Clinicalreview Understanding the role & mechanistic actions of protein kinase inhibitors as an drug target for cancer and #COVID19
📌 https://link.springer.com/article/10.1007/s00203-023-03559-z
📌 https://link.springer.com/journal/203/volumes-and-issues/205-7

#IDMastodon @eLife #clinicalreview #Viralimmunology #Cellimmunity In this #ClinicalReview , multiple researchers with wide-ranging expertise in adult and #pediatricmedicine came together to review the role of the innate and adaptive immune systems in the pathogenesis of acute #SARSCoV2 infection and PASC / #LongCovid .The focus on immune mechanisms here emphasizes the dysregulation of immune processes that are intertwined with the #viralpersistence and tissue-specific pathologies

#IDMastodon #Immunology #oncologyresearch #Clinicalreview @Nature Understanding #mTORpathway & Mechanisms underlying the effects of #rapamycin on healthspan / lifespan . Role of mTOR inhibition on host #immunity & #CancerTherapy
📌 https://www.nature.com/articles/s43587-023-00416-y#Sec11
📌 https://www.nature.com/nataging

#DrugDevelopment @NatRevDrugDisc #Clinicalreview Summarize progress with #COVID19 #DrugDiscovery based on accumulated findings since #COVID19pandemic began & a comprehensive list of clinical and preclinical inhibitors with #Antiviral activities.
📌https://www.nature.com/articles/s41573-023-00672-y
📌 https://www.nature.com/nrd/articles?type=review-article
🧵by @imedverse
https://twitter.com/imedverse/status/1651032814467313664?s=61&t=Yz-0chnQVfpDSt8bfrGiCw

#IDMastodon #clinicalreview The relationship between hypovitaminosis D and thrombosis in #COVID19 / #LongCovid
📌 https://journals.lww.com/bloodcoagulation/Fulltext/2023/04000/The_interplay_between_hypovitaminosis_D_and_the.1.aspx
📌 https://pubmed.ncbi.nlm.nih.gov/36966750/
📌 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866644/
📌 https://journals.lww.com/bloodcoagulation/Pages/currenttoc.aspx

#IDMastodon #Immunology #Hematology #ICU #Clinicalreview #Thromboembolism understanding of the pathophysiological, molecular, and cellular signalling pathways that contribute to #SARSCoV2-related blood clot development @MedicineLWW
https://twitter.com/castltrastondrs/status/1637772919429378050?s=61&t=Yz-0chnQVfpDSt8bfrGiCw

#Cancerimmunotherapies & #interferongamma #ClinicalReview Double-edged roles of IFNγ in tumor elimination and immune escape .Tragetting target IFNγ signaling to overcome immune evasion . A promising therapeutic strategies for the treatment of cancer patient
📌 https://journals.lww.com/jpancreatology/Fulltext/2023/03000/Double_edged_roles_of_IFN__in_tumor_elimination.2.aspx
📌 https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00230-9?rss=yes&utm_source=dlvr.it&utm_medium=twitter#%20

@Nature #Clinicalreview Pain-resolving immune mechanisms in #NeuropathicPain
📌 https://www.nature.com/articles/s41582-023-00777-3.pdf
📌 https://www.nature.com/articles/s41577-019-0147-2.pdf?pdf=button%20sticky

#IDmastodon #Clinicalreview #PedsICU Management of #Neonatal CNS #viralinfections Knowledge gaps and research priorities. Viral infections affecting the CNS such as congenital cytomegalovirus ,enteroviruses ,human parechovirus ,herpes simplex viruses cause significant morbidity and occasional mortality in neonates.
📌 https://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2421
📌 https://onlinelibrary.wiley.com/toc/10991654/0/0

#Cellbiology #IDMastodon #Immunology @aaas #Clinicalreview Understanding the association between The extracellular matrix and the #immunesystem work and how immune cells dictate ECM complexity.
https://www.science.org/doi/epdf/10.1126/science.abp8964

#neurooncology #Clinicalreview @JAMA #Epidemiology & Summarise the current evidence regarding diagnosis & treatment #glioblastoma of primary malignant #braintumors in adults. (🇬🇧🇺🇸)
📌https://jamanetwork.com/journals/jama/fullarticle/2801673?guestAccessKey=541f9650-068c-438f-bb4a-3129f879ab3c&utm_source=twitter&utm_medium=social_jama&utm_term=8978262349&utm_campaign=article_alert&linkId=202462288
📌https://jamanetwork.com/journals/jama/currentissue

#IDMastodon #IDtwitter #Cellimmunity #Immunology #Clinicalreview #Biomarkers related to biological functions in #LongCovid .There are 113 biomarkers Cytokine/Chemokine ,Biochemical markers ,Vascular markers , Neurological markers ,Acute phase protein & Others @FrontMedicine
https://www.frontiersin.org/articles/10.3389/fmed.2023.1085988/full#.Y-EUQ5H5bZg.twitter

#IDMatodon @JCI_insight @StanfordMed These #clinicalreview demonstrate that anti-cytokine and #autoantibodies are common across different viral including #SARSCoV2 and nonviral infections and range in severity of illness.
📌 https://insight.jci.org/articles/view/163150?utm_content=buffer1d797&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

#oncologynutrition @DovePress This narrative #clinicalreview summarises the main findings of observational studies (case-control and cohort) as well as systematic reviews & meta-analyses on the role of nutrients ,dietary patterns on #pancreaticcancer risk & elucidates possible mechanisms for the association between nutrients or specific food components & the risk
📌 https://www.dovepress.com/getfile.php?fileID=86654
📌 https://www.dovepress.com/cancer-management-and-research-archive55-v1745

#IDMastodon #publichealth @thelancetinfdis #Clinicalreview Risk of and #COVID19vaccines effectiveness against infection with the #omicronvariant of #SARSCoV2 in adolescents vaccinated with 2 doses of 30 μg BNT162b2 vs two doses of 10 μg #BNT162b2
📌https://www.thelancet.com/action/showFullTableHTML?isHtml=true&tableId=tbl1&pii=S1473-3099%2823%2900005-1
📌 https://www.thelancet.com/journals/laninf/home
📌 https://www.thelancet.com/issue/S1473-3099(23)X0002-4

#IDMastodon #Clinicalreview Association between the infection probability of #COVID19 and ventilation rates: An update for #SarsCoV2 variants & also suggest that common air purifiers have little effect on reducing the risk of infection, while their effect can be amplified if N95 😷 are worn. Therefore, wearing N95 masks is a very cost-effective prevention

📌 https://link.springer.com/content/pdf/10.1007/s12273-022-0952-6.pdf?pdf=button

#IDMastodon #Molecularbiology #ClinicalReview @aaas Protein decoys for 🦠 may battle #COVID19 and Drugs designed to resemble pathogen’s cellular targets could prevent infection
https://www.science.org/content/article/protein-decoys-viruses-may-battle-covid-19-and-more

#CriticalCareMedicine @BiomedCentral @Crit_Care #ClinicalReview finds that early nutrition support in #ICU is significantly associated with increased mortality at day 28. This may challenge the current guidelines and practices, particularly concerning patients at low nutrition risk.
https://ccforum.biomedcentral.com/articles/10.1186/s13054-022-04298-1?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_BMC