🐣 Our April issue is online today!

This month's cover highlights an article on #ShearStress control of vascular leaks and #atheromas.

Also in this issue: articles on #BreastCancer, #NeuralStemCells, #PrematureOvarianInsufficiency, #Psoriasis, #CLN1, & much more!

🗞️ Fully #openaccess: https://www.embopress.org/toc/17574684/2023/15/4

#CLN1 disease is caused by a deficiency of palmitoyl-protein thioesterase 1 (PPT1). This is one of the most aggressive childhood neurodegenerative diseases with unmet medical needs. Here, the authors provide evidence of the efficacy of a novel approach of #HematopoieticStemCell -based #GeneTherapy in the #CLN1 mouse model.

By M. Peviani, A. Biffi & colleagues

#Openaccess: https://doi.org/10.15252/emmm.202215968

Content Warning: Child experiencing seizures.

Not my usual Amelia post, but these are dacrystic seizures. They can cause involuntary crying and tears. She might also feel sad, but she can’t tell us.

Another reason why #BattenDisease is horrible and why we need funding for clinical trials NOW. #clinicaltrials #cln1 #raredisease #rarediseases