Join us Thurs, April 27 at noon CT/1 pm ET as Dr. Fernando Camargo of Boston Children’s Hospital presents “Lineage Histories and Function in the Hematopoietic System.” Camargo’s work is aimed at dissecting the lineage trees of developing tissues and how understanding where cells come from might provide insights into the developmental origins of cancer. Register. https://bit.ly/SOCC23-MAS #SOCC23 #CancerResearch #ClonalHematopoiesis

RT @humanimmunenews
Scientists at @DanaFarberNews review:
1️⃣ connection between #clonalhematopoiesis and pathological immune dysfunction
2️⃣ clinical and therapeutic implications of clonal hematopoiesis as a target for #immunomodulation
3️⃣ and more!

In @NatRevImmunol:
📑 https://go.nature.com/3Z9ziqk

Concise & timely review from my colleague Sarah Reed out in #AACR #ClinicalCancerResearch about #ClonalHematopoiesis in #SolidTumors. See the nice summary figure below and find the full text here: https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-22-2598/711363/CHIP-Happens-Clonal-hematopoiesis-of-indeterminate #medicine #science #hematology #oncology #cancer #immunology

Interesting study in #ScientificReports that did #transcriptome profiling of surgically-removed calcified aortic valves from patients with/without #ClonalHematopoiesis. The authors found broad changes to immune cell infiltrates but also to #antibody profiles that correlated with survival. This last point is cool because CH's impact on #myeloid biology is often discussed, but it can obviously have important effects on #lymphoid cells, too: https://www.nature.com/articles/s41598-022-24130-8 #science #medicine #cardiology

Nice review on the #biology of #ClonalHematopoiesis that covers both acquired point mutations (i.e., CHIP) and large mosaic chromosomal alterations (mCAs). I especially like this figure summarizing known risk factors for each. Full text here: https://www.sciencedirect.com/science/article/abs/pii/S1931524422002511 #hematology #genetics #genomics #science #medicine

One way that mutated immune cells might lead to an observed increase in #cardiovascular disease is through secretion of inflammatory #cytokines. In this recent abstract, the authors analyzed levels of 1,300 serum proteins for their association with #ClonalHematopoiesis mutations, finding that #TET2 mutations had several strong associations. Interesting to me that different CH mutations have different cytokine profiles, despite converging on increased #CVD risk: https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.15719 #omics