Engineered bacteria detect tumor DNA. Synthetic biology has developed sophisticated cellular biosensors to detect, respond to human disease. Here, we engineered naturally competent Acinetobacter baylyi to detect donor DNA from genomes of #colorectalcancer (CRC) cells, organoids, and tumors. We characterized the functionality of the biosensors in vitro with coculture assays and then validated them in vivo with sensor bacteria delivered to mice harboring colorectal tumors. https://www.science.org/doi/full/10.1126/science.adf3974

Updated #guidelines on #colonoscopy surveillance | #BCMJ https://bcmj.org/articles/updated-guidelines-colonoscopy-surveillance
“Recent evidence has demonstrated that individuals with low-risk #precancerous lesions that are resected during colonoscopy are not at significant risk of future #ColorectalCancer compared with the general population and do not require intense colonoscopy surveillance. Conversely, individuals with high-risk precancerous lesions that are removed appear to benefit from surveillance colonoscopy”

My left ankle and foot are hurting in new and exciting way. Hopefully I just need a new AFO and nothing's messed up too bad. Cancer is just an endless parade of crap. #colorectalcancer

The influence of COVID-19 on colorectal cancer was investigated using bioinformatics and systems biology techniques. https://doi.org/10.3389/fmed.2023.1169562 #Covid19 #ColorectalCancer #DifferentiallyExpressedGenes #GeneOntology #Protein–ProteinInteraction

Ina Sonnen of the #HubrechtInstitute and I were granted a 4-year funding to theoretically and experimentally study role of #SignallingDynamics in formation, progression and treatment of #ColorectalCancer. Watch out for #PhD and #PostDoc positions.
https://www.hubrecht.eu/dutch-cancer-society-grants-for-geert-kops-and-ina-sonnen/

A new study found the risk of colorectal cancer,
For young men, was a major factor
Exercise, a poor diet, smoking and drinking,
Are all factors increasing the risk, we should be thinking
Early screening should be done, it's the key
To catch this disease, before it's too late to flee

#colorectalcancer #earlyscreening #highrisk #youngmen #poetry

http://www.medicalnewstoday.com/articles/colorectal-cancer-earlier-screening-should-be-considered-for-young-men-at-high-risk

@statto The approach is being investigated in other solid #cancers like #melanoma or #colorectalcancer as well: reduce tumor burden with surgical resection and then add vaccination to the adjuvant (maximum) treatment...ideally a blueprint for success. Let's see what the trials will show... #immunology #immunotherapy

@old_hippie #BreastCancer #ProstateCancer #ColorectalCancer

“Instead, they saw a difference with the fungi Cladosporium sp., which appeared more often in the tumors of early-onset colorectal cancer patients. A series of other bacteria were more common in the tumors of older patients and not found at all in younger patients.” #isogg #dna #epigenetics #cancer #colorectalcancer #geneadons https://www.axios.com/2023/05/26/new-bacterial-clues-young-people-colorectal-cancer

RT @cellhostmicrobe
Fuso induces tumor resistance to #immunotherapy. New work reports that Fusobacterium nucleatum-derived succinic acid diminishes sensitivity to anti-PD-1 mAb in #ColorectalCancer by impairing CD8+ #Tcell-mediated antitumor immunity https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00161-0

Referenced link: https://medicalxpress.com/news/2023-04-unravels-pathophysiological-role-dectin-colorectal.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-04-unravels-pathophysiological-role-dectin-colorectal.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1645436740658778113#m

RT by @physorg_com: Study unravels pathophysiological role of Dectin-1 in promoting #colorectalcancer @TUS_PR @NatureComms https://www.nature.com/articles/s41467-023-37229-x https://medicalxpress.com/news/2023-04-unravels-pathophysiological-role-dectin-colorectal.html

*From #TumorBoardTuesday archives*

📖A lot can change in a year in ctDNA. Take a look at this January 2022 #ColorectalCancer case presentation by @aparna1024 & wrap up

Is there something you'd do different?
@MPishvaian @JohnEbbenMDPhD @pashtoonkasi

---
RT @TumorBoardTues
1/11
#TumorBoardTuesday case🎀⏲️

👉Deploying ctDNA to guide IO in #crc
🔥 topic led by @aparna1024

Read on for primer on mgmt of rectal ca w 🧬tools!

First…
https://twitter.com/TumorBoardTues/status/1481799635601707015

Check out some #CoolScienceImages from a Science Advances study. Chun et al. revealed a mechanistic link between #circadian clock disruption and #ColorectalCancer.

https://www.science.org/doi/10.1126/sciadv.abo2389

Music: #dreams by #Gryffin

#FluorescenceFriday
#colorectalcancerawarenessmonth
#colorectalcancerawareness
#crcawarenessmonth
#crcawareness

Check out some #CoolScienceImages from a Science Advances study. Chun et al. revealed a mechanistic link between #circadian clock disruption and #ColorectalCancer.

https://www.science.org/doi/10.1126/sciadv.abo2389

Music: #dreams by #Gryffin

#FluorescenceFriday
#colorectalcancerawarenessmonth
#colorectalcancerawareness
#crcawarenessmonth
#crcawareness

Referenced link: https://medicalxpress.com/news/2023-03-sox9-protein-enables-molecular-colorectal.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-sox9-protein-enables-molecular-colorectal.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1641138195063533568#m

RT by @physorg_com: Sox9 protein enables molecular 'time travel' that can lead to #colorectalcancer @danafarber @ScienceAdvances https://medicalxpress.com/news/2023-03-sox9-protein-enables-molecular-colorectal.html

RT @BenLevyCello
Amazing virtual concert Thurs, March 30 at 8 PM EDT. Stream free @ http://GI.org/Concert Tune It Up: A Concert for Colorectal Cancer Awareness. Featuring Jon Batiste, Hilary Hahn, Ally Venable with Buddy Guy, Cincinnati Pops. #concerts #music #ColorectalCancer @AmCollegeGastro

RT @AmCollegeGastro
🎶Tune It Up: A Concert to Raise Awareness of #ColorectalCancer

🗓️Thurs. March 30th at 8pm Eastern

Concert Master Dr. Ben Levy has outdone himself with incredible artists this year!

🎵Go to http://gi.org/concert for livestream🎵

#ColorectalCancerAwarenessMonth
#GItwitter

RT @TumorBoardTues
#TumorBoardTuesday

🧬How do we use anti-EGFR tx in metastatic #colorectalcancer? A discussion led by @shafiarahman_ @RischZack

➡️Here’s the Thursday Case 🎀

🆓 #CME by answering 2 ❓
ALL CME 🔗: http://integrityce.com/TBT2023
CME eval🔗: http://integrityce.com/TBTeval23

RT @JohnEbbenMDPhD
A huge thank you to @shafiarahman_ & @RischZack for presenting us with the latest data in #EGFR targeting in #metastatic #ColorectalCancer.

Excited to see how 🩸🧬#ctDNA can help us design rational strategies to better use EGFR therapies particularly with re-challenge. https://twitter.com/JohnEbbenMDPhD/status/1639072110139125761

RT @JohnEbbenMDPhD
A huge thank you to @shafiarahman_ & @RischZack for presenting us with the latest data in #EGFR targeting in #metastatic #ColorectalCancer.

Excited to see how 🩸🧬#ctDNA can help us design rational strategies to better use EGFR therapies particularly with re-challenge. https://twitter.com/JohnEbbenMDPhD/status/1639072110139125761