First accurate data on dynamic #molecular #aggregates in #cells.

#microscopy #fluorescence #condensates #NELF

https://phys.org/news/2023-08-accurate-dynamic-molecular-aggregates-cells.html

Study explains how part of the #nucleolus #evolved.

#organelles #TCOF1 #condensates #fibrillar_center

https://phys.org/news/2023-08-nucleolus-evolved.html

Specialized molecular aggregates in cells. Keys to signalling.
#MolecularAggregates #Condensates #StressSignaling #Chaperones #Science #Microscopy
https://phys.org/news/2023-08-accurate-dynamic-molecular-aggregates-cells.html

This is really cool- great to see #singlemolecule *molecular* scale behaviour inside #condensates: https://www.nature.com/articles/s41586-023-06329-5

Chromatin-associated condensates dysregulation in mendelian disorders

Università di Trento

#EU-funded #PhD project to address the contribution of #chromatin #condensates to define of the #genome architecture and nuclear #mechanobiology

See the full job description on jobRxiv: https://jobrxiv.org/job/universita-di-trento-27778-chromatin-associated-condensa...
https://jobrxiv.org/job/universita-di-trento-27778-chromatin-associated-condensates-dysregulation-in-mendelian-disorders/?feed_id=47152

“A University of Chicago study found links at the atomic level between photosynthesis and #exciton #condensates—a strange state of physics that allows energy to flow frictionlessly through a material. The finding is scientifically intriguing and may suggest new ways to think about designing electronics”

#UChicago
#Photosynthesis
#BoseEinstein

https://news.uchicago.edu/story/scientists-find-link-between-photosynthesis-and-fifth-state-matter

Newly discovered #electrical activity within #cells could change the way researchers think about biological chemistry.

#condensates #cytoplasm

https://phys.org/news/2023-04-newly-electrical-cells-biological-chemistry.html

Ph.D. position in Biological Physics @ZwickerGroup

Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.

https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696

#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696

Postdoctoral Position in Biological Physics @ZwickerGroup

Come join us at @mpids for an @ERC_Research funded #postdoc position to develop models of viscoelasticity of biomolecular #condensates.

https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=38116

#ScienceJobs #job @mpids #ER...
https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=38116

🧬 Malfunctioning #condensates in the cell can lead to the rare BPTA syndrome, but also common diseases. This is a new disease mechanism, discovered by @dhnisz @malte_spielmann @henri_niskanen et al. at @ChariteBerlin @UKSH_KI_HL & published in @Nature

🔗 https://www.molgen.mpg.de/4600883/

🧬 Malfunctioning #condensates in the cell can lead to the rare #BPTA syndrome, but also common diseases. This is a new #DiseaseMechanism, discovered our researchers in collaboration with #Charité Berlin and #UKSH, and published in the journal @Nature

https://www.molgen.mpg.de/4600883/

Ph.D. position in Biological Physics @ZwickerGroup

Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.

https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462

#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462

Postdoctoral Position in Biological Physics @ZwickerGroup

Come join us at @mpids for an @ERC_Research funded #postdoc position to develop models of viscoelasticity of biomolecular #condensates.

https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=36081

#ScienceJobs #job @mpids #ER...
https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=36081

Happy to share new collaborative work on #singlemolecule imaging of biomolecular #condensates. They're less uniform than they seem! With #PappulabWashU @TingtingWu #MattKingLab #MinaFaragSci #WashUengineers

"Single fluorogen imaging reveals spatial inhomogeneities within biomolecular condensates"
https://doi.org/10.1101/2023.01.26.525727

Ph.D. position in Biological Physics @ZwickerGroup

Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.

https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=35286

#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=35286

RT @ZwickerGroup@twitter.com

Happy to announce an @ERC_Research@twitter.com funded #postdoc position in our group. Potential projects include viscoelasticity of biomolecular #condensates and related topics. Deadline is March 1. More details: https://www.ds.mpg.de/3993062/job_full_offer_19772722
@TheoBiophysics@twitter.com #TheoBiophysicsPosition

🐦🔗: https://twitter.com/ZwickerGroup/status/1617550411275325441

...they 'just' correlate. It could very well be that the formation of condensates is a consequence of the difference observed rather than the cause. It could very well be that #condensates are a byproduct, a passive result of physical-chemical properties of highly abundant non translated mRNAs and their interacting proteins, and don't have a function per se. This, I would argue, should be the working model, until proven wrong. The end. 5/5

Let me rant about #condensates a propos this commentary👇. IMHO it illustrates a lot of the things that are wrong in #biology. From the top we are told "researchers are trying to work out how these ubiquitous beads form and what they do" [the condensates]. I would argue the first question should be "do they do anything?", but biologists abandoned 'Ockham's razor' long ago. The most parsimonious explanation would be condensates have no function... 1/n

#CellBiology #CellBio
https://www.nature.com/articles/d41586-022-03477-y

#Biomolecular #condensates and #PhaseSeparation are getting significant attention in the #signaling field. Here are two papers implicating condensates in #Hippo signaling. In the first, #cancer-initiating cells adopt a glycogen storing mode that blocks Hippo signaling through phase separation. In the second, antagonizing condensates control Hippo signaling without dissolution, via multiphase coalescence.
https://www.sciencedirect.com/science/article/pii/S0092867421011752
https://www.sciencedirect.com/science/article/pii/S0092867422012557

@MM2022 would the approach in your preprint also work the other way round, to analyze experimental (FTIR) data of an IDP and get info on different subensembles (I only read the first part so far) - it defines looks very interesting- in my lab we are doing FTIR and multidimensional / 2D-IR on peptide systems involved in forming #protein #condensates and a link to computational analysis would be very helpful