Julien Delpierre · @JulienDelpierre
180 followers · 214 posts · Server qoto.org
"[...] a tension-dependent signal on the #nucleus that sets the time for nuclear envelope permeabilization (NEP) and mitotic entry. This signal relies on #actomyosin #contractility, which unfolds the nucleus during the G2-M transition, activating the stretch-sensitive #cPLA2 on the nuclear envelope and regulating the nuclear translocation of #cyclin B1.[...]"
https://rupress.org/jcb/article-abstract/221/12/e202205051/213539/Nuclear-tension-controls-mitotic-entry-by
#BioMechanics #MechanoBiology #NuclearTension #CellBiology #CellCycle #CellDivision #NuclearEnvelope #NuclearTranslocation #CellCompression #GenomicInstability
#cPLA2 #biomechanics #mechanobiology #NuclearTension #cellbiology #NuclearTranslocation #CellCompression #nucleus #actomyosin #contractility #cyclin #cellcycle #celldivision #NuclearEnvelope #GenomicInstability
⎯ΘωΘ⟶ · @yog
203 followers · 852 posts · Server mathstodon.xyz#Micro #filaments are usually about 7 nm in #diameter and #made up of #two #strands of #actin. Microfilament #functions #include #cytokinesis, #amoeboid #movement, #cell #motility, #changes #in #cell #shape, #endocytosis and #exocytosis, #cell #contractility, and #mechanical #stability. #Microfilaments are #flexible and #relatively #strong, #resisting #buckling by #multi #piconewton #compressive #forces and filament #fracture by #nanonewton #tensile #forces.
#tensile #nanonewton #fracture #Forces #compressive #piconewton #multi #buckling #resisting #strong #relatively #flexible #Microfilaments #stability #mechanical #contractility #exocytosis #endocytosis #shape #in #changes #motility #cell #movement #amoeboid #cytokinesis #include #functions #actin #strands #two #made #diameter #filaments #micro