“Our research shows that #siRNA treatment can target the #virus in key regions that do not change as the virus evolves, which means it works across all current #variants of concern. Most importantly, we envisage that it will also work for existing and future #SARS #coronaviruses that emerge,”

“siRNA can stop #SARSCoV2 replication by directly targeting the virus itself, which means there is no immune system involvement,” https://med-mastodon.com/@LordsofHardwired/110874679883984122

#COVID19's #PatientsZero May Have Been #Wuhan #Lab #Scientists. The first 3 people to contract COVID-19 were scientists working at the Wuhan Institute of Virology a finding that could confirm #LabLeak theory of COVID-19's #origins, if verified. Not only did these 3 scientists work at the WIV, they worked specifically on gain-of-function research; Hu in particular was considered a "star pupil" of #ShiZhengli dubbed "bat woman" for her work studying #coronaviruses in #bats. https://reason.com/2023/06/16/covid-19-patients-zero-wuhan-lab-leak-shellenberger/

“This study provides new evidence that bat-borne #coronaviruses can and do spill over to people, underscoring the importance of surveillance in high-risk rural areas, where humans and wildlife closely interact”

https://www.ucdavis.edu/health/news/bat-borne-sarbecoviruses-spilled-over-southeast-asia-pre-pandemic

This is promising. “In cell-based assays, the antibody bound to four separate families of coronaviruses, including SARS-CoV-2.”
Especially considering the recent discoveries of 2 recombinant Canine CoVs (one of which had segments shared with a felid CoV) in sick children (Malaysia & Haiti). Finding conserved proteins btw CoVs in all genera or families could be useful for vaccine development.
#covidvaccine #coronaviruses

https://www.science.org/content/article/covid-19-virus-mutated-outsmart-key-antibody-treatments-better-ones-coming

"Before 2002, no in-depth information was available on human CoVs (HCoVs) and their zoonotic potential. The emergence of the first highly pathogenic HCoV in 2002, SARS-CoV-1, the subsequent epidemic MERS-CoV, and the pandemic SARS-CoV-2, opened “Pandora’s box” on CoVs." I remember my virology textbook (~1984) had a half-page on coronaviruses. We've come a long way, but not done yet.
Very interesting review from animal pathology perspective. #virology #coronaviruses

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143937/

#SARS arose from #coronaviruses in Horseshoe Bats. This image is included in the video as proof that the origin was a live animal market. The bats shown are Fruit Bats. In 2003, were Horseshoe Bats ever sold in the same location as Civet Cats and Raccoon Dogs? Are/were Horseshoe Bats ever collected commercially? Are they used in superstitious potions and supplements? If so, the hunter/ preparer, not the consumer of a dried product is at risk.

https://www.youtube.com/watch?v=rZRc0ClQRUI

#OriginofCovid

#Bats in disrupted #ecosystems are more infected with #coronaviruses, reveals study.

#landuse #disturbance

https://phys.org/news/2023-04-disrupted-ecosystems-infected-coronaviruses-reveals.html

How did farmed animals become infected? Is there any reason to believe that bats had been collected to be fed to the farmed animals? Are free roaming domestic cats kept on farms in the area for rodent control?
# # #
Farmed animals might have their own #Coronaviruses . Does #sarscov2 show any recombination with these?

Veterinary and trade journals in China might have answers. Congress could provide money to have these translated.

https://trueinfections.com/080922.html

@adamr de Chardin noted the need not to think of the past as some sort of dusty attic. The past is something deep in a way that defies superficial comprehension. Similarly viruses and their evolution are extremely difficult to compare to events on a human scale. Those seeking SARS CoV 2 in the wild are right up there with Nietche's madman lighting the streetlamps in the day to find God.
#OriginofCovid #sarscov2 #Coronaviruses #virology

Archived pre-2020 human blood samples from Myanmar show 12% seropositivity against a range of SARS-like coronaviruses not previously known to infect humans, with over 30% among people who work forest extractive industries or handle #bats.

https://www.ijidonline.com/article/S1201-9712(23)00064-4/fulltext

#OneHealth #EpiVerse #OpenAccess #Epidemiology #Coronaviruses

🔬Researchers have identified antibodies that could be effective against SARS-CoV-2 and future #coronaviruses.

The #EUFunded #ATAC project aims to develop antibody therapy for #COVID19 & share results to support the medical community.

Find out more ➡️ https://europa.eu/!9vv3q3

🐦🔗: https://n.respublicae.eu/CORDIS_EU/status/1630211369868861440

RT @IMBA_Vienna
#Review article in @cellcellpress

The @penningerlab with @GOuditResearch and IMBA PhD student Max Kellner review the role of #ACE2 (the entry receptor for multiple #coronaviruses) in the #COVID19 pandemic.

@viennabiocenter @TrainingVbc @ubclifesciences @oeaw #Coronavirus

1/2 https://twitter.com/CellCellPress/status/1620878049553297408

@cyrilpedia TL/DR: they found a dog Coronavirus, and it seems that similar spillovers happen all of the time all over the world; but most spread poorly in people.

Knowing how common this is can help monitoring for spillovers that can spread more effectively in people.

#SpillOver #InfectiousDisease #Coronaviruses

Rethinking next-gen vaccines for #CoronaViruses and other respiratory viruses https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00572-8#%20

What would help eventually is if we ever figure out how to give everyone whatever magic #immunity exists in those people who still have not had a noticed #Covid infection despite almost certain exposure.

My bet would be on that coming from the work towards a #vaccine that mimics a stable region on the virus which is common across all #coronaviruses. That could end Covid. Maybe.

#CovidIsntOver

Considering the concern about molnupiravir, perhaps Laurie Garrett was right 8 years ago.
# # #
...
32:18
20-fold increased mutation rate all right is anybody worried about that
32:24
not really or you won't tell me if you're worried about it okay well it's uh is that okay lori's worried
32:29
about that dr garrett is worried about that all right so um why can i ask you why
32:35
you're worried about it
...
# # #
https://youtu.be/Aw-nR6-4kQQ?t=1800
#Virology #Coronaviruses #molnupiravir #GOF

Correlated #substitutions reveal #SARS-like #coronaviruses recombine frequently with a diverse set of structured #gene #pools https://www.pnas.org/doi/abs/10.1073/pnas.2206945119?af=R

US Office of Inspector General: The National Institutes of Health and EcoHealth Alliance Did Not Effectively Monitor Awards and Subawards, Resulting in Missed Opportunities to Oversee Research and Other Deficiencies

https://oig.hhs.gov/oas/reports/region5/52100025.asp

#Virology #Coronaviruses #Wuhan #WIV

N.I.H. Did Not Properly Track a Group Studying #CoronaViruses, Report Finds https://www.nytimes.com/2023/01/25/science/nih-ecohealth-coronavirus-lab-leak.html

Unredacted NIH Emails Show Efforts to Rule Out Lab Origin of #COVID19 https://theintercept.com/2023/01/19/covid-origin-nih-emails/ Among other things, the NIH helped fund experiments at WIV that infected genetically engineered mice with “chimeric” hybrids of SARS-related bat #coronaviruses in what some scientists have described as unacceptably risky research. As The Intercept has reported, these particular experiments could not have sparked the pandemic — the viruses described in the research are too different from SARS-CoV-2