The EMBO Journal · @embojournal
411 followers · 98 posts · Server sciencemastodon.com
Viral mimicry of a #DCAF #ubiquitin #ligase adaptor: #CryoEM shows how rodent #cytomegalovirus #CMV E27/M27 hijacks host cell #CRL4 #cullin-RING E3s to degrade #STAT2 and suppress #antiviral #interferon signaling
https://www.embopress.org/doi/10.15252/embj.2022112351
#dcaf #Ubiquitin #ligase #cryoem #cytomegalovirus #cmv #crl4 #cullin #stat2 #Antiviral #interferon
The EMBO Journal · @embojournal
403 followers · 85 posts · Server sciencemastodon.com
Protein complex assembly #qualitycontrol in action:
#cryoEM structures by Nico Thomä at FMI and colleagues show how #CRL4-#DCAF12 #ubiquitin E3 #ligase engages a C-terminal di-Glu #degron in CCT5 recognizable only when this subunit is not incorporated into the #TRiC/#CCT #chaperone complex
https://www.embopress.org/doi/10.15252/embj.2022112253
#qualitycontrol #cryoem #crl4 #dcaf12 #Ubiquitin #ligase #degron #tric #chaperone