Integrating cytokine adsorber post-dialyzer into #CRRT circuit in critically ill patients with liver failure, data from Cyto-SOLVE study showed decreased ammonia plasma-concentration but
🟤 no evidence for relevant ammonia-clearance by Cytosorb®
🟤 elimination mainly achieved by dialyzer (constant clearance over time depending on blood flow & effluent rate)
@ICM
🖇️ https://rdcu.be/c5scg

🟤 The few studies on #CRRT use in patients with acute liver failure have large limitations & focused mainly on its use if concomitant #AKI. CRRT membranes reduce ammonia levels and could be an adjunctive therapy, but could not be considered liver support or salvage therapy https://rdcu.be/c3X8z

🟤 In reply to https://rdcu.be/cZpbg

🟤 Refers to consensus statements for artificial liver support, in failure due to variable etiology, including graft failure after #Tx. https://rdcu.be/cU7s2

At first, I found it hard to get my head around citrate anticoagulation for CRRT. I built a module to help others understand what I learned

https://osler.app.link/PduAGD12Hvb

Hope you find it helpful too

#medmastodon #medtwitter #CRRT #criticalcare #intensivecare #intensivecarenurse #intensivecaremedicine #intensivist #ICU #ICUnurse #renal #dialysis #citrate

Veno-pulmonary #ECMO configuration through double lumen cannula in patients with #COVID19 related #ARDS, systematic review. Still limited published literature and evidence on implementing the configuration, providing both respiratory and right ventricular support, in this population. Anyway, available data suggest lower rates of mortality, #AKI/need for #CRRT compared to other respiratory support modalities (both dual site or single site approaches).
📎 https://bit.ly/3j09kq0