Postdoc in cryo-EM method development

Delft University of Technology

Join us to develop a new generation of #cryoEM sample supports!

See the full job description on jobRxiv: https://jobrxiv.org/job/delft-university-of-technology-27778-postdoc-in-cryo-em-method-development/?feed_id=58402

#ScienceJobs #hiring #research
Delft #Netherlands #PostdoctoralFellow
https://jobrxiv.org/job/delft-university-of-technology-27778-postdoc-in-cryo-em-method-development/?feed_id=58402

Ever wondered if you could skip purification and do in silico purification of clarified lysate fractions from the #cryoem images? Dmitry Semchonok and others from the Kastritis lab at the University of Halle answered that question successfully in this recent publication https://doi.org/10.1016/j.yjsbx.2023.100094!

PhD student in Cryo-ET studies of membrane trafficking

Max-Planck-Institute for Multidisciplinary Science

Join us @mpi_nat for #PhD to study #MolecularMachines driving #membranetrafficking by #cryoEM #cryoET #temtomo.

See the full job description on jobRxiv: https://jobrxiv.org/job/max-planck-institute-for-multidisciplinary-science-27778-p...
https://jobrxiv.org/job/max-planck-institute-for-multidisciplinary-science-27778-phd-student-in-cryo-et-studies-of-membrane-trafficking/?feed_id=57731

PhD Position in Cryo Electron Microscopy of Rhodopsin Cyclases

University of Potsdam

Come join us #UniSysCat as a #PhD student in #CryoEM

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-potsdam-27779-phd-position-in-cryo-electron-microscopy-of-rhodopsin-cyclases/?feed_id=56532

#ScienceJobs #hiring #research
Potsdam/Berlin #Germ...
https://jobrxiv.org/job/university-of-potsdam-27779-phd-position-in-cryo-electron-microscopy-of-rhodopsin-cyclases/?feed_id=56532

PhD student in Cryo-ET studies of membrane trafficking

Max-Planck-Institute for Multidisciplinary Science

Join us @mpi_nat for #PhD to study #MolecularMachines driving #membranetrafficking by #cryoEM #cryoET #temtomo.

See the full job description on jobRxiv: https://jobrxiv.org/job/max-planck-institute-for-multidisciplinary-science-27778-p...
https://jobrxiv.org/job/max-planck-institute-for-multidisciplinary-science-27778-phd-student-in-cryo-et-studies-of-membrane-trafficking/?feed_id=56213

I regret to inform you that someone has spunked into a ~£6m electron microscope, all in the name of science.

Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility
#StructuralBiology #CryoEM #Science

https://pubmed.ncbi.nlm.nih.gov/37295417/

I'm currently seeking work (contract or full-time). I'm a developer and system administrator with significant experience managing infrastructure and building tools for scientific and clinical work, most recently working with Python, Linux, and HPC systems supporting cryo-em.

I live in central Maryland and cannot relocate, so I have to stick to either relatively local areas or remote work.

#FediHire #CryoEM

Cortactin stabilizes actin branches by bridging
activated Arp2/3 to its nucleated actin filament

Lovely bit of work this. 4 figures as well.
#StructuralBiology #CryoEM @strucbio
http://biorxiv.org/cgi/content/short/2023.08.16.553490v1?rss=1

#CryoEM models of spliceosomal complexes containing Prp16 show it in its nucleotide-free state: here the first structure of Prp16 in complex with a nucleotide is presented.
@unigoettingen

@ActaCrystF

@IUCr
#DEAHBoxHelicases #Prp16 #spliceosome https://doi.org/10.1107/S2053230X23005721

@JoachimFrank

Wow: “In an operating range from 10 to 1000 ms, the device allows us to follow in vitro reactions of biological molecules at resolution levels in the range of 3 Å. By employing this method, we show for the first time the mechanism of progressive HlfX-mediated splitting of the 70S E. coli ribosome in the presence of the GTP, via capture of three high-resolution reaction intermediates within 140 ms.” —Bhattacharjee et al. 2023 https://www.biorxiv.org/content/10.1101/2023.01.25.525430v2.full

#StructuralBiology #CryoEM #ribosome

We were super happy to be able to discuss revolutionary new #hexaufoil #cryoem grids and Quantifoil Active for SPT Labtech chameleon with Instructinate at #MM2023. Check out the video now! https://lnkd.in/ef-FqKnu 😎😍

Meharry Medical College graduate student KeAndreya Morrison highlighted a Cell Reports publication with contributions from SBGrid member Peter Kwong of the National Institute of Allergy and Infectious Diseases (NIAID) in which the authors describe improved HIV neutralizing antibodies using OSPREY, an open-source protein design software.

https://www.tumblr.com/sbgridconsortium/724367027985416192/a-new-method-for-hiv-antibody-design

#science #SBGrid #antibodies #cryoem #research

<ALT= Cyro-EM structure of PG9RSH Y(100k)D variant>

#DistributedComputing & #CitizenScience vs #COVID19: Rechenkraft.net hat auf Basis der #CryoEM-Struktur PDB 7JZL aus der @RosettaAtHome Publikation https://science.sciencemag.org/content/early/2020/09/08/science.abd9909 die Interaktion zwischen Designerpeptid LCB1 (orange) und #SARSCoV2 Spikeprotein herausgearbeitet.

PhD Position in Cryo Electron Microscopy of Rhodopsin Cyclases

University of Potsdam

Come join us #UniSysCat as a #PhD student in #CryoEM

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-potsdam-27779-phd-position-in-cryo-electron-microscopy-of-rhodopsin-cyclases/?feed_id=53014

#ScienceJobs #hiring #research
Potsdam/Berlin #Germ...
https://jobrxiv.org/job/university-of-potsdam-27779-phd-position-in-cryo-electron-microscopy-of-rhodopsin-cyclases/?feed_id=53014

After the excitement of #MM2023, we are enjoying the calm of the iconic Walker Gallery in Minneapolis, only to discover our #cryoem grids in the artwork... Or are we just obsessed? With thanks to the artist Pacita Abad

Former PhD student from our lab (now postdoc-ing at LMB) is making great progres..

#StructuralBiology #CryoEM @strucbio #Science #Research #Academia

How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00511-7?rss=yes

As we come to the end of our Festival of #cryoem Grids at #MM2023, we have questions. Why is @cjrlab MRC LMB so good at Jenga? How can Adriana Klyszejko from Quantum Detectors Ltd. so accurately guess the number of grids? Why do I talk so much? Most importantly, is that a man dressed as a chameleon?? 😎 😍 We had a fabulous time introducing the world to HexAuFoil and Quantifoil Active for chameleon - looking forward to seeing you all again in Cleveland next year!

Ecited to share our work on how ECF #transporters use ATP binding to charge a molecular spring and tune the #membrane shape to expel membrane-embedded substrate-binding proteins from the docking site into the membrane. #cryoEM #Biochemistry #MDsimulations https://rdcu.be/dhJvy

Placing #steroid hormones within the human #ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket
This #cryoEM study uses the location of two substrates to reveal a common steroid-binding pocket
https://www.embopress.org/doi/full/10.15252/embj.2022113415

Technical Notes: Our June software push includes updates to BioXTAS RAW, careless, DIALS, DiffDock, IMOD, OpenMM, RNA Structure, ShapeMapper2, Topaz, Xplor-NIH.

https://sbgrid.org/software/recent/archive/

#SBGrid #Software #Crystallography #cryoem #molecules