Collectively, our study provides insights on the relationship of cTfh with non-cTfh cells and on the #heterogeneity and #persistence of #antigen-specific #human #cTfh cells.

We thank all colleagues that had put efforts into this project, the blood donors, and all institutions for supporting our work.

Enjoy the reading!

In this study we combined antigenic stimulation and T cell receptor (#TCR) Vβ sequencing to investigate the clonal composition of #antigen-specific #human #cTfh. In particular:

In this study we combined antigenic stimulation and T cell receptor (#TCR) Vβ sequencing to investigate the clonal composition of #antigen-specific #human #cTfh. Collectively, our study provides insights on the relationship of cTfh with non-cTfh cells and on the #heterogeneity and #persistence of #antigen-specific #human #cTfh cells.

We thank all colleagues that had put efforts into this project, the blood donors, and all institutions for supporting our work.
Enjoy the reading!
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We are happy to share our new study recently published in the European Journal of Immunology entitled “Clonal composition and persistence of antigen-specific circulating T follicular helper cells”.
https://onlinelibrary.wiley.com/doi/10.1002/eji.202250190

Follicular helper T cells (Tfh) are very important to promote #Bcell response and #antibody affinity maturation. Despite, their blood counterparts circulating Tfh (#cTfh) cells are poorly defined in #human in terms of #antigen specificity and persistence. 1/2