@Cureus In #COVID19 cases along with #diabetes, due to #Hyperglycemia there may be decreased viral response. A delay in the interferon-gamma response along with a prolonged hyperinflammatory state & reduced number of CD4 , CD8 may exacerbate the ‘ #cytokinestorm’ and produce a devastating state of the disease
https://www.cureus.com/articles/133623-a-case-of-post-covid-19-rhino-cerebral-mucormycosis-in-an-immunocompromised-patient#!/

@frontimmunol by producing interferon & drives the accumulation of pro-inflammatory chemokines and cytokines. creating a “#cytokinestorm” that invades and damages the central and peripheral nervous system, leading to #neuroinflammation & #demyelination .
#COVID19 and the risk of NMOSD : a Mendelian randomization study
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1207514/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit

Recent studies have shown uncontrolled and exacerbated antiviral responses can enhance the recruitment of neutrophils, monocytes, and other immune cells which leads to the creation of cytokine storms by overproduction of IFN-γ, TNF-α, GM-CSF, MCP-1, IL-6, IL-2, and IL-8 . The #cytokinestorm is a major life-threatening condition associated with #COVID19
https://karger.com/iaa/article/184/6/557/835878/T-Cell-Immune-Responses-and-Immunological-Factors

Referenced link: https://medicalxpress.com/news/2023-06-apple-shaped-obesity-cytokine-storm-higher.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-apple-shaped-obesity-cytokine-storm-higher.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1671195971789701122#m

RT by @physorg_com: Apple-shaped obesity is associated with #cytokinestorm and a higher risk of death in COVID-19 patients @TMDUniversity @PNASNews https://pnas.org/doi/10.1073/pnas.2300155120 https://medicalxpress.com/news/2023-06-apple-shaped-obesity-cytokine-storm-higher.html

Referenced link: https://medicalxpress.com/news/2023-05-covid-patients-wasnt-cytokine-storm.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-05-covid-patients-wasnt-cytokine-storm.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1654202423240544288#m

RT by @physorg_com: What really killed #COVID-19 patients: It wasn't a #cytokinestorm, suggests study @northwesternu @jclinicalinvest https://www.jci.org/articles/view/170682 https://medicalxpress.com/news/2023-05-covid-patients-wasnt-cytokine-storm.html

#IDMastodon #CaseReport hemophagocytic lymphohistiocytosis triggered by infection.The most common infectious agents that provoke the development of HLH are 🦠 (41 %), mycobacteria (23 %), other bacteria (23 %) ,fungi (13 %). Previously, EBV is the most common viral pathogen due to its ability to cause clonal proliferation & hyperactivation of T-cells .At present, the probable viral pathogens is #SARSCoV2, the severe course of #COVID19 is associated with the development of #cytokinestorm

#IDMastodon IL-26 Potential Biomarker for Acute #COVID19
⏫IL-26➡️#cytokinestorm .Antiviral effect IL26➡️Novel Tx.
📌 https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016991/full
📌 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361342/
📌 https://coronavirus.health.ny.gov/covid-19-breakthrough-data
📌 https://www.fda.gov/consumers/consumer-updates/know-your-treatment-options-covid-19
🧵https://twitter.com/castltrastondrs/status/1593298189003759618?s=61&t=Qv8rr3WRZyxRmYud8_ZbXg

#IDMastodon IL-26 Potential Biomarker for Acute #COVID19
📌https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016991/full
📌 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361342/
📌 https://coronavirus.health.ny.gov/covid-19-breakthrough-data
📌 https://www.fda.gov/consumers/consumer-updates/know-your-treatment-options-covid-19
IL-26 may be a biomarker of acute #COVID19 & ⏫IL-26➡️#cytokinestorm .Antival effect IL26➡️Noval Tx.

#IDmastodon The idea that #SarsCoV 2 can be tamed to become a mild illness if only the “#cytokinestorm” from our nasty immune system is knocked out, needs to be
questioned. #Immunosuppression in #COVID19 is likely to encourage deep-seated viral engraftment and #longCOVID. 🧵@ToshiAkima
📌 https://twitter.com/toshiakima/status/1592682682080985088?s=61&t=ub9JL53L3C5-9M7c6j9VYQ
📌https://www.sciencedirect.com/science/article/pii/S0344033822003508

#IDmastodon Baricitinib versus tocilizumab treatment for hospitalized adult patients with severe COVID-19 and associated cytokine storm: A prospective, investigational, real-world study .All-cause mortality was similar between adults treated with baricitinib or tocilizumab for severe #COVID19 with #cytokinestorm
📌https://www.sciencedirect.com/science/article/pii/S120197122200577X
📌https://www.sciencedirect.com/journal/international-journal-of-infectious-diseases
@ISID_org

#Oncotwitter #IDTwitter In #cohortstudy of 12046 cancer & #SARSCoV2 infected patients who with #Immunotherapy & systemic anticancer Tx in the context of baseline #immunosuppression was associated with ⏫incidence of #cytokinestorm & worse outcomes https://jamanetwork.com/journals/jamaoncology/fullarticle/2797979 @JAMAOnc
https://t.co/M520rqczin