Prepared for war: How #cells survive #viral invasion.

#transcriptomics #cytomegalovirus

https://phys.org/news/2023-06-war-cells-survive-viral-invasion.html

Cytomegalovirus lies dormant in most US adults and is the leading infectious cause of birth defects, but few have heard of it.

https://tinyurl.com/56wy49h2

#cmv #cytomegalovirus #birthdefects #pregnancy nancy

Das #Cytomegalovirus ist ein #Herpesvirus, das lange im Körper überdauern kann. Eine neue Studie des HZI-#Virologen Luka Cicin-Sain mit der Vetmeduni Wien und der Universität Rijeka im Journal Nature Communications zeigt erstmals, dass #CMV dafür die gleichen Bindegewebszellen nutzt wie zur Vermehrung.
https://www.helmholtz-hzi.de/de/aktuelles/news/news-detail/article/complete/ein-virus-auf-der-lauer-im-bindegewebe/

Former STAT intern Edward Chen does a deep dive into neonatal #cytomegalovirus or #CMV — the damage it can do and the debate over whether universal screening makes sense. https://www.statnews.com/2023/04/05/cmv-screening-congenital-cytomegalovirus-hearing-loss/

Babies born with congenital #CMV infection may have long-term health problems. The most common long-term health problem is hearing loss. #Cytomegalovirus infection is regulated by Glycoprotein B (gB) making it a target for neutralizing antibodies and a vaccine candidates. This 3D printed molecular model HCMV Glycoprotein B visualizes where neutralizing antibodies bind the glycoprotein and used by healthcare provides to discus therapies.  https://biologicmodels.com/pdb/5c6t/human-cytomegalovirus-hcmv-glycoprotein-b/

Viral mimicry of a #DCAF #ubiquitin #ligase adaptor: #CryoEM shows how rodent #cytomegalovirus #CMV E27/M27 hijacks host cell #CRL4 #cullin-RING E3s to degrade #STAT2 and suppress #antiviral #interferon signaling
https://www.embopress.org/doi/10.15252/embj.2022112351

"The team hypothesised that some of the T cells specific to SARS-CoV-2 had been activated by a herpesvirus called human #cytomegalovirus (HCMV). This pathogen is highly prevalent in the population and has also been linked to changes in the severity of #COVID19 symptoms (Alanio et al., 2022). To investigate, they stimulated pre-pandemic blood samples with different segments of SARS-CoV-2 proteins. This led them to discover a population of ‘cross-reactive’ CD4 and CD8 T cells that can recognize epitopes from both #SARSCoV2 and #HCMV"

https://elifesciences.org/articles/85080?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

CMV symptoms: Mother who passed cold-like virus onto her daughter was told she’d never walk or talk | The Independent

Courtney Farnell caught common cytomegalovirus (CMV), a virus that causes cold-like symptoms, eight weeks into her pregnancy
#pregnancy
#CMV
#Cytomegalovirus
#Disabilty
#Hygiene

https://www.independent.co.uk/life-style/health-and-families/cmv-virus-symptoms-cytomegalovirus-b2260952.html

@jonaskunst

very interesting finding re: negative association of neurocognitive symptoms in Long Covid w/ CMV.

also, from article: "CMV seropositivity in younger adults is actually associated with heightened adaptive immune responses to influenza vaccination ..., despite earlier studies in the aging literature linking CMV to immunosenescence phenotypes"

#cytomegalovirus #CMV
#immunology #neuroscience #aging #brain #science

#Human #cytomegalovirus infection of epithelial cells increases #SARS-CoV-2 #superinfection by upregulating the #ACE2 receptor, The Journal of Infectious Diseases, jiac452, https://doi.org/10.1093/infdis/jiac452

https://www.lewrockwell.com/2021/12/no_author/what-they-are-not-telling-you-about-covid-19-hospitalizations-deaths-and-what-you-can-do-about-it/

There is agreement that Covid-19 co-infection with #cytomegalovirus is associated with higher rates of mortality in older people who have an aged (senescent) immune system.

What They Are Not Telling You About Covid-19 Hospitalizations & Deaths And What You Can Do About It
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https://www.liebertpub.com/doi/10.1089/vim.2021.0150

“For instance, with cytopathic #cytomegalovirus, infected cells initially elevate the … ”

Controlling the Burden of COVID-19 by Manipulating Host Metabolism