RT @CellReproLab
We would like to introduce Carl 1st to the world - the first cured animal with #reprogramming in Lund! An outcome of the REPRINT European consortium to establish proof-of-principle for new cancer immunotherapy based on in-vivo reprogramming of tumor cells to #dendritic cells🎉 https://twitter.com/AsgardThx/status/1645757081348190208

Severe #COVID19 patients have impaired plasmacytoid #dendritic cell-mediated control of #SARS-CoV-2 https://www.nature.com/articles/s41467-023-36140-9

Could #ADHD and #autism be related to the way my mind is constantly going off on tangents, because it's going through a series of thoughts about some Primary Thing, and then it makes some connection to some related Secondary Thing, and then *feels compelled* to explore that new idea? It's almost #fractal. Or #dendritic. because these thought branches have their own thought branches.

Hello. I'm me from the future. I just started a new post with something about it being a new trunk, as opposed to a branch. I found this post again, because I'm trying to go back and remember what that new post was going to be about.

What I'm doing is making available to read the kind of free associative, stream of consciousness doodle typing that I should have been doing for the past 30 years just as a warmup exercise to generate ideas for things to ACTUALLY write about.

I don't know. Maybe it was laziness. Actually no, it's because I can't write with a pencil with one fifth of the speed and fluency I can at a keyboard.

I also LOATHE the sight of my handwriting. Actually, I'm ashamed of it, but I don't want to shimmy along that branch.

Anyway, what I did was unconsciously condition myself to scan every thought experience for Something To Write A Story About beginning around the age of 13. I'm literally doing it now. I keep pausing to think of examples or metaphors for things I'm talking about, and my inner attentiveness starts following it

*DING* I just had to answer a text message from a colleague who was answering a question I didn't know I didn't have to ask #becauseautism. Where the fuck am I?

What is going on with our immune cells after COVID-19 infection?

This thread will explore some of the impacts of #COVID #infection on our #immune system even after people are recovered including:
- Missing naive #T-cells
- Exhausted T-cells
- Loss of #B-cell maturation
- Hyper-activated #inflammatory response
- Immune system is impeded post-infection
- #Immunological #dysfunction persists 8+ months
- #Depletion and dysfunction of #dendritic cells

🧵 1/

How complex #immunology becomes in clinical translation: consider that not only the timing of #vaccination but also the localization (arm versus flanks) can have an impact on efficacy and effect in terms of activation of #dendritic cells, #antigen presentation and effector #lymphocyte stimulation... #circadian rhythm and #Localization , with summary for timings here:
https://scim.ag/QC

#IMMUNITY | A TAXONOMICAL RETHINK 🤔 | Reclassifying #Plasmacytoid #Dendritic #Cells as# #Innate #Lymphocytes | 🗣

"With respect to their ontogeny, emerging data support a lymphoid origin of plasmacytoid dendritic cells (pDCs), which seem to share a developmental trajectory with B cells. By contrast, conventional dendritic cells (DCs) have a myeloid origin in the common dendritic cell progenitor.
1/2