#leukocytes in particular need to be recruited within short time frames because immunological threats arise at unpredictable sites in the body. Moreover, #Adaptiveimmunity is generated in #lymphatic organs, which are usually remote from the primary site of infection, requiring long-range cellular trafficking.
#dendriticcells can “self-shape” the chemotactic gradients that help them transport antigens to lymph nodes, @SciImmunology

Scientists have described a previously unappreciated mechanism in #DendriticCells that exacerbates the severity of allergic airway responses—and show that targeting this pathway can soothe airway allergies in mice. @SciSignal https://scim.ag/3h9 #press

"Mechanistically, glycolysis augmented ATP production to boost STING activation and STING-dependent DC antitumor functions. Moreover, DC-intrinsic STING activation accelerated HIF-1a–mediated glycolysis and established a positive feedback loop."

#Immunology #immunotherapy #DendriticCells #Metabolism

https://www.jci.org/articles/view/166031

In the middle of an excellent seminar in which Matthias Gromeier presented work on Cancer Immunotherapy with Recombinant Poliovirus, the Zoom session was ended and no luck from the organization's side to restart. 😭

The first 10-15min showed work linking back to original work and ideas from Albert Sabin and David Bodian. Specific targeting of #DendriticCells and #Macrophages, #interferon response.

Hopefully they recorded the seminar.

#cancer #immunotherapy

The paper focuses on #DendriticCells (DC) and #monocytes from a local inflammatory site, in this case synovial fluid from swollen joints of mainly juvenile #arthritis patients.
Very short: one type of DC were very much enriched but seemed relatively quiescent despite the inflammatory surroundings, while other DC and monocytes behaved clearly pro-inflammatory.

Last week, the paper based on my work in the Wilhelmina Children's Hospital (WKZ) was published, with the title "Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis".
https://doi.org/10.3389/fimmu.2022.1101999

Credits to Anoushka Samat for taking care of this after I left the department. Without her this work would not be out there. And of course thanks to the rest of the team.

#immunology #RNAseq #inflammation #DendriticCells #monocytes

Check our last contribution to study #CellMigration in #DendriticCells, by #LolaH and @LpzLpz_Tami
(Thanks to @renkawitzteam for the invitation)

There is a lot more assays to have fun !

Full @EurJImmunol: https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202249925

Here goes the #dendriticcells merrily via #lymphatics taking antigens - the presents for #Tcells . Will they take them? What will they do? Best xmas card from #CellCartoons hope she comes to mastodon soon!

Y’all, this thread by @jeffgilchrist is so important and good. All about #Covid and our emerging understanding of its deleterious effects on #immunity.

#immunesystem #Tcells #dendriticcells #naiveTcells

https://mstdn.science/@jeffgilchrist/109558435801043562

Dear people interested in #organoids #Tcells #Macrophages #Bcells #DendriticCells #MucosalImmunology #microbiome #OrganOnChip #MicroPhysiologicalSystems #IBD #CeliacDisease #iPSCs,

where are you? I want to follow you!

Best regards,
Me

'This article (...) provides detailed protocols for the preparation of single-cell suspensions from various mouse nonlymphoid tissues, including skin, intestine, lung, kidney, mammary glands, oral mucosa and transplantable tumors, and instructions for multiparameter flow cytometry analysis of DC subsets.'

#Immunology #DendriticCells #FACS #FlowCytometry

https://onlinelibrary.wiley.com/journal/15214141

RT @PittetLab@twitter.com

Again, #dendriticcells are shown to play a critical role in tumor control. But it's necessary to involve them at the right time of day😀
Thank you @ScheiermannLab@twitter.com for the privilege of working with you and being able to contribute a small part of your work!
https://doi.org/10.1038/s41586-022-05605-0

🐦🔗: https://twitter.com/PittetLab/status/1600525946108448769

RT @eballestar@twitter.com

Happy to share our study showing #VitaminC boosting #immunogenicity properties of #DendriticCells through NF-κB- & #TET2 driven #DNAdemethylation ⁦@octaviompa@twitter.com⁩ ⁦@GerardGodoy3@twitter.com⁩ ⁦@JoseL_Sardina@twitter.com⁩ ⁦⁦@Eva_M_C@twitter.com⁩ ⁦@CarrerasIJC@twitter.com⁩ https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac941/6777795

🐦🔗: https://twitter.com/eballestar/status/1587739956100812800

The article by Korniotis et al. showing that GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization is #openaccess: https://journals.biologists.com/jcs/article/135/21/jcs260298/281775/GM-CSF-activated-human-dendritic-cells-promote

#research #cellbiology #immunology #dendriticcells #openscience

RT @jkagan1@twitter.com

@corner_tx@twitter.com @harvardmed@twitter.com @BostonChildrens@twitter.com #immunotherapy #sitc #inflammasomes #innateimmunity #dendriticcells #immunityforlife

🐦🔗: https://twitter.com/jkagan1/status/1590702551930122241