#introduction. I am a plant developmental geneticist. The lab addresses a fundamental biological question: how does morphogenesis translate genotype into form? To this end we study signaling at the plasma membrane - cell wall interface and we investigate how mechanical forces influence tissue shape using 3D digital ovules.

Main interests:
#Arabidopsis #CellBiology #cellbio #CellWall #devbio #devbiol #DevelopmentalBiology #EvoDevo #imaging #lignin #MechanoBiology #microscopy #PlantBiology

Very important for the field of #connectomics is the measurement of stereotypy in neuronal number and morphology within identified cell types–most neurons in the #Drosophila brain are uniquely identifiable and stereotyped.

The stereotypy is very strong across brains – these are excellent news for experimental robustness, i.e., mapping circuits in one brain and performing behavioral and functional experiments in many others.

#neuroscience #DevBiol #Drosophila

"A consensus cell type atlas from multiple connectomes reveals principles of circuit stereotypy and variation", by Schlegel et al. 2023 (Greg Jefferis lab at #MRCLMB in collaboration with the Bock, Murthy, and Seung labs, and also Volker Hartenstein)

Interesting to me in particular, and here I see the hand of Volker Hartenstein (my postdoc adviser!), is the annotation of developmental units: the neuronal lineages (Fig 2 below).

#Drosophila #connectomics #neuroscience #DevBiol

"Phylogenetic tracing of midbrain-specific regulatory sequences suggests single origin of eubilaterian brains", by Schuster and Hirth, 2023 https://www.science.org/doi/10.1126/sciadv.ade8259

A genetic signature of bilateral animals with brains, including "a genetic boundary separating the rostral from caudal nervous systems, demonstrated for the metameric brains of annelids, arthropods, and chordates and the asegmental cycloneuralian and urochordate brain"

In other words, the genetic toolkit of the ancestor of both protostomes (arthropods, nematodes, molluscs and annelids) and deuterostomes (echinoderms and vertebrates) – the eubilaterian.

https://www.science.org/doi/10.1126/sciadv.ade8259

#neuroscience #DevBiol #EvoDevo #NeuroEvo #evolution

@eLife

New work on the #chinmo gene that controls fly larval development, by Sílvia Chafino et al. 2023 https://elifesciences.org/articles/84648

… building on prior work by Truman & Riddiford 2022 https://www.pnas.org/doi/abs/10.1073/pnas.2201071119 on “Chinmo is the larval member of the molecular trinity that directs Drosophila metamorphosis”

#Drosophila #DevBiol #metamorphosis

@eLife

“Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting”, by Wong et al. 2023 (Liqun Luo’s lab). https://elifesciences.org/articles/85521

#neuroscience #DevBiol #Drosophila

@flypapers

#connectomics meets #transcriptomics to explain synaptic specificity in #Drosophila:

Yoo et al. 2023
http://biorxiv.org/content/10.1101/2023.04.03.534791v1

#neuroscience #DevBiol

:happy: Just found this on the bird net :happy:

📣 📣 📣 Delighted to distribute the announcement of the 6th European Cilia conference CILIA2024

I can't wait to meet everyone and present our work in Dublin!

To those not familiar with cilia and flagella: these are the greatest organelles of all 😊

#Cilia2024 #Cilia2022 #RareDisease #ADPKD #BBS
#DevBiol #CellBiology #Science
@cilia

In our eighteenth 'Transitions in development' #interview, Cross-Title Reviews Editor Daniel Routledge speaks to Jingli Cao about his #career path, his experience of becoming a group leader and his love for #astronomy

https://journals.biologists.com/dev/article/150/7/dev201703/306216/Transitions-in-Development-an-interview-with

#devbio #careers #devbiol #stemcells

@scottishwaddell

You are welcome–it's been fun to discover an entirely different slice of science and research here, starting this past October. My presence in the other side is nominal, keeping an account there as a flag and pointer to here. The move gave me the chance to follow more entomology accounts and learn more about insects and small invertebrates I'd like to map some day. Also: one has to follow more accounts here to sample the #neuroscience and #DevBiol fields as broadly as we did on the other side, as the only promotion algorithm is the boost button.

In other news, this week we installed a Bruker SkyScan microCT in the lab, courtesy of the #MRCLMB (I love this place), and we are over the moon. It's essential to quality-control samples that proceed to electron microscopy for #connectomics. But it's also going to prove useful to scan whole small animals densely at 0.5 to 1 µm isotropic resolution.

Este 2023 de llevará a cabo el 2°congreso colombiano de Biología del Desarrollo, en Medellín. El registro está abierto.

The second Colombian Congress of Developmental Biology is approaching. To register, just scan the QR code

#biology #developmentalbiology #developmental #colombia #medellin #devbiol #DevBio

16p11.2 microdeletions increase variability in #neurodevelopment

A Research Highlight showcasing new work from Rana Fetit, David Price & colleagues
https://journals.biologists.com/dev/article/150/4/e150_e0403/292573/16p11-2-microdeletions-increase-variability-in

Read the #ResearchArticle, '16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic #organoids' in our #HumanDev section
https://journals.biologists.com/dev/article/150/4/dev201227/288407/16p11-2-deletion-accelerates-subpallial-maturation

'The people behind the papers' interview series
https://journals.biologists.com/dev/article/150/4/dev201685/288408/The-people-behind-the-papers-Rana-Fetit-and-David

#devbio #devbiol #stemcells

Registration is now open for our 2023 Meeting 'Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology' organised by Swathi Arur, James Briscoe, Gautam Dey and Cassandra Extavour

Apply at https://biologists.com/meetings/unconventional-organisms-23

#devbio #devbiol #DevMeeting23

Developmental Twists: The Italian Journey

Tsuku Mogami gives a unique perspective on a popular Valentine's Day gift

https://journals.biologists.com/dev/article/150/3/dev201629/286912/Developmental-Twists-The-Italian-Journey

#devbio #valentinesday #devbiol #rose

The recordings from January's Development presents... webinar featuring Simon Freedman, Mindy Liu Perkins and Kirsten ten Tusscher, and the Q&A with chair Paul Francois are now available to watch on @the_node

https://thenode.biologists.com/development-presents-january-videos/development-presents/

#DevPres #webinar #devbio #devbiol #modelling

Excited to share our new study combining in vivo CRISPR perturbation sequencing with barcode-based lineage tracing. The study reveals a mechanism by which selective enhancer activation establishes the identity of GABAergic projection neurons. Our work may help to understand the mechanism of disease associated with Meis2 mutations.
https://www.biorxiv.org/content/10.1101/2023.01.30.525356v1
#neuroscience #devbio #devbiol #Genomics #NGS #Genetics #science #neuro #neurodevelopment

Excited to share our new study combining in vivo CRISPR perturbation sequencing with barcode-based lineage tracing. The study reveals a mechanism by which selective enhancer activation establishes the identity of GABAergic projection neurons. Our work may help to understand the mechanism of disease associated with Meis2 mutations.
https://www.biorxiv.org/content/10.1101/2023.01.30.525356v1
#neuroscience #devbio #devbiol #Genomics #NGS #Genetics #science #neuro #neurodevelopment

Excited to share our new study combining in vivo CRISPR perturbation sequencing with barcode-based lineage tracing.
https://www.biorxiv.org/content/10.1101/2023.01.30.525356v1
#neuroscience #devbio #devbiol #Genomics #NGS #Genetics #science #neuro #neurodevelopment

Excited to share our new study combining in vivo CRISPR perturbation sequencing with barcode-based lineage tracing. The study reveals a mechanism by which selective enhancer activation establishes the identity of GABAergic projection neurons. Our work may help to understand the mechanism of disease associated with Meis2 mutations.
https://www.biorxiv.org/content/10.1101/2023.01.30.525356v1
#neuroscience #devbio #devbiol #Genomics #NGS #Genetics #science #neuro #neurodevelopment

Cre recombinase method for single-cell tracing in mouse embryos

A Research Highlight showcasing work from Miquel Sendra, Miguel Torres and colleagues

https://journals.biologists.com/dev/article/150/3/e150_e0302/286903/Cre-recombinase-method-for-single-cell-tracing-in

Read the full #OpenAcess Techniques and Resources article, 'Cre recombinase microinjection for single-cell tracing and localised gene targeting' here:

https://journals.biologists.com/dev/article/150/3/dev201206/286898/Cre-recombinase-microinjection-for-single-cell

#Dev_journal #dev #DevBio #devbiol