@frontimmunol #dexamethasone attenuates interferon-related cytokine hyperresponsiveness in #COVID19 patients
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1233318/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit

#IDMastodon #pharmaimmunology #Immunology Understanding the anti-inflammatory impact of #dexamethasone on the pathways contributing to cytokine hyperresponsiveness observed in severe manifestations of #COVID19, incl type I/II IFN signaling. Dexamethasone could have adverse effects in Mild #COVID19 by inhibiting IFN responses in early stages of the disease, whereas it exhibits beneficial effects in patients with severe clinical phenotypes by efficiently diminishing cytokine hyperresponsiveness.

In an early stopped trial, dexamethasone was not found to be NON-INFERIOR to surgical drainage to treat chronic subdural hematoma.

Dexamethasone is associated to greater number of complications and to a higher probability of later surgery.

#Dexamethasone #Subdural #Hematoma @nejm

https://www.nejm.org/doi/full/10.1056/NEJMoa2216767

#IDMastodon @jamanetworkopen this #Clinicalinvestigation of 80 699 patients early #dexamethasone use is associated with improved mortality or discharge to hospice among patients requiring supplemental oxygen or mechanical ventilation and/or extracorporeal membrane oxygenation.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2803926

#COVID news 3/31/23

"#Dexamethasone has been shown to help treat severe acute COVID infections and now we know how. A new study shows that dexamethasone affects ion channel-mediated immune cell function, including #cytokine production, to decrease risk of cytokine storm and death"

4/n

https://drruth.substack.com/p/covid-news-and-more-33123

Peter Horby “RECOVERY pre-print out.
In hypoxic hospitalised COVID-19 patients requiring either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared to usual care, which included low dose corticosteroids.”
#COVID19
#Dexamethasone
#RECOVERY
#Hypoxia
#LowDoseIsBetter

https://www.medrxiv.org/content/10.1101/2022.12.16.22283578v1

His thread at https://twitter.com/peterhorby/status/1604774719294619648?s=46&t=c-yh5b05N5xtYA50a31Bbw

#IDMastodon In this cohort study of 6,671 patients whose respiratory status deteriorated while receiving DEXA6 for COVID-19 pneumonia, and the findings do not support escalating patients with #COVID19 pneumonia who deteriorate on low-dose #corticosteroids to high-dose #dexamethasone or #anakinra.
https://www.sciencedirect.com/science/article/pii/S1201971222006038?dgcid=raven_sd_aip_email @ISDA

#dVax #dNews #Covid #Vaccine #Jab #MonoclonalAntibodies #Regeneron #Dexamethasone
-

** URGENT from Rand Paul **
NEW COVID-19 TREATMENTS!

Recently, four DOUBLE-JABBED friends in Alaska caught COVID. They were high risk, ages 60-95! GREATLY IMPROVED by the next day!

EARLY THERAPEUTICS:
Regeneron Monoclonal Antibodies*
Dexamethasone
Zinc
Vitamins C & D
*Must be started in first 10 days!

https://www.regencov.com/hcp/dosing/dosing-administration
--
https://www.healthline.com/health-news/mon

** URGENT from Rand Paul **
NEW COVID-19 TREATMENTS!

1/1/2021 updated #corona drug cocktail:

all phases:
#Famotidine
#Indomethacin
#Spironolactone
#Ivermectin
#VitaminD
#VitaminC

Mild:
#Bromhexine
#Omeprazole/ #Nitazoxanide
#Fluvoxamine
#Aspirin
#Naproxen

Moderate:
#Remdesivir
inhaled #Interferon
#Colchicine
inhaled #Ciclesonide + #Mometasone
#Dipyridamole
JAK inhibitors such as #Baricitinib / #Tofacitinib

Severe:
#Dexamethasone/ #Methylprednisolone
#Cyproheptadine

cc @noorul@quey.org @stux
https://nitter.net/Mareeswj/status/1344748390001774593?s=20

Enhancing shareholder value at the cost of a scared public...

RT @cspramesh@twitter.com

The last old drug we repurposed for #COVID_19 had 6425 patients - #RECOVERY trial for #Dexamethasone. A 30 patient study is not enough to prove efficacy even for an old drug. And as for "doctors seeing outstanding results", the plural of anecdote is not data - Clinical Trials 101 https://twitter.com/fayedsouza/status/1282633755065151493

@noorul@quey.org @stux #COVID_19 #COVID__19 update

buy PulseOximeter at home

Fever - #Azythromycin/#Doxycycline

Low SPO2 - #Dipyridamole + proning + complete rest OR hospital admission

Anti-histamine(allergy)/gut problem - #Famotidine

Immunity booster - #Quercetin + #vitamin_C

BP & Cardio protection - #Losartan + #statins

Prophylaxis - #Dutasteride/#Finasteride/#Bicalutamide/#Degarelix/#HCQ

Anti-inflammatory - #Dexamethasone, #Methylprednisolone, #colchicine

Anti-viral - #Remdesivir/#Favipiravir

RT @SimpleCorrect@twitter.com

#COVID19: L’#OMS interrompt le volet #hydroxychloroquine de son essai clinique Solidarity | via @heidi_news@twitter.com
Et non, ce n'est pas un complot de #BigPharma. Un autre traitement semble bien plus prometteur, lui aussi bon marché et connu: la #dexamethasone
https://www.heidi.news/sante/l-oms-interrompt-le-volet-hydroxychloroquine-de-son-essai-clinique-solidarity?utm_source=twitter

🐦🔗: https://twitter.com/SimpleCorrect/status/1273901098248605696

Note: only works for critical patients on ventilators, so don't start gulping this down 'just to be safe'.

"The drug, called dexamethasone, is the first shown to reduce deaths from the coronavirus that has killed more than 430,000 people globally. In the trial, it cut deaths by about one-third in patients who were on ventilators because of coronavirus infection."

https://www.nature.com/articles/d41586-020-01824-5

#COVID19 #Drugs #Dexamethasone