The EMBO Journal · @embojournal
451 followers · 195 posts · Server sciencemastodon.com
How can #metabolic & #environmental cues modulate the #DNAdamage response? María Moriel-Carretero et al find master kinase #Tel1/ATM to bind #PI4P at the #Golgi, altering its availability in the nucleus and impacting kinetics, intensity and persistence of DNA DSB responses in yeast and human cells
#metabolic #environmental #dnadamage #tel1 #pi4p #golgi #refereedpreprint
The EMBO Journal · @embojournal
426 followers · 140 posts · Server sciencemastodon.com
A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage
#protelysis #Recombination #knoten1 #ubp12 #ubiquitination #autophagic #BLM #rmi1 #dnadamage
Dr. Eti Ost 👩🏫 👩🔬 🇨🇦 · @EtiOst
241 followers · 454 posts · Server mastodon.world
This is serious 😨
#SARSCoV2 infection induces #DNAdamage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence.
#Covid #health #MedMastodon
https://www.nature.com/articles/s41556-023-01096-x?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO
#COVID #SarsCoV2 #dnadamage #health #MedMastodon
The EMBO Journal · @embojournal
415 followers · 109 posts · Server sciencemastodon.com
Surprising interplay between #SMC5/6 and #transcription-regulating #PAF1 complexes in #Arabidopsis #DNAdamage response:
Shunping Yan and colleagues find them to interact and recruit E2/E3 enzymes for #histone H2B #ubiquitination at DNA double-strand breaks
https://www.embopress.org/doi/10.15252/embj.2022112756
#smc5 #transcription #paf1 #arabidopsis #dnadamage #histone #ubiquitination
RoedigerRG · @RoedigerRG
12 followers · 24 posts · Server social.anoxinon.deWe are always interested in students for bachelor and master theses. The topics range from #bioinformatics, #bioanalytic|s to medical #pharmacological topics. For example, we are investigating whether #CBD has a DNA damaging effect (DSB, DNA double strand break). We would be happy to find someone who wants to work with #brain #organoids.
#DSB #dnadamage #bachelorthesis #masterthesis #fedijob #organoid
#bioinformatics #bioanalytic #pharmacological #cbd #brain #organoids #dsb #dnadamage #bachelorthesis #masterthesis #fedijob #Organoid
The EMBO Journal · @embojournal
411 followers · 100 posts · Server sciencemastodon.com
How do select pre-#mRNAs escape 3’ end-processing inhibition by #DNAdamage?
Stephan Vagner and colleagues (Institut Curie) invoke rescue by a #cotranscriptional cleavage that allows subsequent #posttranscriptional #polyadenylation site processing in the nucleoplasm
Now published, previously a #RefereedPreprint via @ReviewCommons
#mrnas #dnadamage #cotranscriptional #posttranscriptional #polyadenylation #refereedpreprint
The EMBO Journal · @embojournal
406 followers · 90 posts · Server sciencemastodon.com
What is the role of #DNAdamage #kinase #DNAPKcs in the cellular response to #oxidative stress?
Benjamin Chen at UT Southwestern, Hsinyu Lee at National Taiwan University, and coworkers implicate it as part of a #checkpoint that modulates #ANT2-#VDAC2-mediated ADP-ATP exchange over #mitochondrial membranes to limit #OXPHOS-derived ROS
#dnadamage #Kinase #dnapkcs #oxidative #checkpoint #ant2 #vdac2 #mitochondrial #oxphos
Journal of Cell Science · @J_Cell_Sci
598 followers · 91 posts · Server mstdn.science
Castro-Obregón &co report that nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components. Transfer from @ReviewCommons. The article is #openaccess thanks to @Co_Biologists' #Readandpublish agreement with Universidad Nacional Autónoma de México:
https://journals.biologists.com/jcs/article/136/1/jcs260563/286548/Nucleophagy-contributes-to-genome-stability
#cellbiology #research #sciencemastodon #science #autophagy #nucleophagy #DNAdamage
#openaccess #readandpublish #cellbiology #research #sciencemastodon #Science #autophagy #nucleophagy #dnadamage
Bernhard Schermer · @cilib
541 followers · 684 posts · Server social.cologne🧬 ❌ 🧬 ❌
"Physiol. Consequences of Genome Instability"
Looking for your enthusiasm and your imagination!
📣 9 positions for PhD applicants are available within the novel research consortium FOR 5504.
Send us your application and join us in :koeln: !
Email to: schumacher-office[at]uni-koeln.de
Please re-toot! 🙏
#Science #PHDstudent #PhDposition #DNA #DNAdamage #Genome #GenomeStability
@UniKoeln
@CECAD
#KidneyResearch #Ciliopathies #Cilia #CellBiology
#science #PhDstudent #PhDposition #dna #dnadamage #genome #genomestability #kidneyresearch #ciliopathies #Cilia #cellbiology
Yan Leyfman, MD · @yleyfman
124 followers · 157 posts · Server med-mastodon.com
Michael S. Glickman · @MichaelGlickma1
69 followers · 50 posts · Server fediscience.orgInteresting and important paper solving structures of the RecA filament bound to the various proteins it activates, including LexA.
https://www.pnas.org/doi/10.1073/pnas.2217493120
Loop 2 of RecA intimately associates with bound LexA. Very strongly complementing our findings that phosphorylation of L2 regulates LexA cleavage in the mycobacterial DDR:
#genomicintegrity #dnadamage #mutagenesis #reca
The EMBO Journal · @embojournal
361 followers · 54 posts · Server sciencemastodon.com
#DNAdamage #DNArepair #kinase #DNAPK and #cGAS synergize to induce cancer-related #inflammation in #glioblastoma
Clara Taffoni, Johanna Marines, Nadine Laguette et al at IGH Montpellier
https://www.embopress.org/doi/10.15252/embj.2022111961
#dnadamage #DNARepair #Kinase #dnapk #cgas #inflammation #glioblastoma
Universität zu Köln · @UniKoeln
416 followers · 22 posts · Server wisskomm.social
***English below***
🧬Strahlenschäden an väterlicher #DNA werden an Nachkommen vererbt. Schäden in Eizellen hingegen werden repariert. Warum? Eine Studie von @schumacherbj in @Nature hat nun die Antwort.
Mehr dazu ➡ https://uni.koeln/65Z3K
🧬Radiation damage to paternal #DNA is inherited to offspring. Damage in oocytes, on the other hand, is repaired. Why? A study by @schumacherbj @Nature now has the answer.
Read more ➡ https://uni.koeln/65YL9
#dna #dnadamage #inheritance #genetics
Hao Yin · @HaoYin
207 followers · 183 posts · Server qoto.org
MEG9/Mirg, a LncRNA in Dlk1-Dio3 cardio-angiocluster, links #DNADamage & #Angiogenesis
⏫by Genotoxic stress
⏬by VEGF/FGF2/Dll4/Jag1
🐭Mirg KO affects s.c. Matrigel vessel stability in a Sex-specific manner
Dr. Cristina Espinosa-Diez & Sudarshan Anand lab bioRXiv 2022
https://www.biorxiv.org/content/10.1101/2022.12.07.519382v1
Pei-Chi Wei · @braingenomes
134 followers · 24 posts · Server genomic.social
RT @APoetsch@twitter.com
We have several postdoc openings!
https://tu-dresden.de/cmcb/biotec/forschungsgruppen/poetsch/jobs
Our interdisciplinary group works on the #Genomics of #DNAdamage and #Mutagenesis using #ComputationalBiology, #MachineLearning and #AI.
(details in following tweets)
#genomics #dnadamage #mutagenesis #computationalbiology #machinelearning #ai
Pierre Caron · @pierrecaron
21 followers · 2 posts · Server pouet.chapril.orgWebinar alert #DNAdamage. The 2022 season of #EDRA webinars will end on December the 13th. The keynote speaker for this event will be Dr. Philippe Pasero who will present his work on the cellular responses to replication stress. If you want to attend to the meeting or give a short talk, just click on this link : https://dnarep.sciencesconf.org/resource/page/id/8
Ari DetCURT · @acdc105
0 followers · 1 posts · Server nerdculture.de
Should be focusing on cell culture. Figuring out Mastodon instead #firsttoot #twittermigration #academia #dnadamage
#firsttoot #twittermigration #academia #dnadamage
Ari DetCURT · @acdc105
0 followers · 1 posts · Server nerdculture.de
Should be focusing on cell culture. Trying to figure out Mastodon instead. #twittermigration #academia #dnadamage
#twittermigration #academia #dnadamage