Mathew Thomas · @mathewthomas
14 followers · 1399 posts · Server mstdn.social
Thiago Carvalho · @cyrilpedia
1889 followers · 10982 posts · Server qoto.org

Crossing the Valley of Death

"In this Review, we quantify the discoveries that have been translated into approved therapies. While acknowledging the decades-long lag time between target identification and regulatory approval of derived therapeutics, we reasoned that addressing this question now is both legitimate and essential to guide future investments in the field."

nature.com/articles/s41586-023

#drugdiscovery #drugdevelopment #pharma

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1892 followers · 10900 posts · Server qoto.org

"On Tuesday, an international team announced in the journal Cell that they had identified a potential new antibiotic lurking unnoticed in the sandy soil of North Carolina. The compound, called clovibactin, employs an unusual method of killing bacteria that makes it tough for targets to develop resistance. While clinical trials in humans are several years away, the finding is a glimmer of hope in an increasingly drug-resistant world."

ft.com/content/a8d62524-3f3f-4

#antibioticresistance #microbiology #antibiotics #drugdevelopment

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1858 followers · 10061 posts · Server qoto.org

"The Food and Drug Administration on Friday approved the first pill for postpartum depression, a milestone considered likely to increase recognition and treatment of a debilitating condition that afflicts about a half-million women in the United States every year."
nytimes.com/2023/08/04/health/

In April I wrote about how this new class of drugs were developed for . Read it at the link below:

nature.com/articles/d41591-023

#sciencecommunication #postpartum #drugdevelopment #scicomm #naturemedicine

Last updated 1 year ago

Tech news from Canada · @TechNews
925 followers · 24415 posts · Server mastodon.roitsystems.ca
Leibniz-HKI · @LeibnizHKI
45 followers · 31 posts · Server wisskomm.social
Tech news from Canada · @TechNews
901 followers · 23850 posts · Server mastodon.roitsystems.ca
Mr.Trunk · @mrtrunk
5 followers · 9464 posts · Server dromedary.seedoubleyou.me
Thiago Carvalho · @cyrilpedia
1832 followers · 9772 posts · Server qoto.org

These ads are all over NY. To learn the history of this new class of weight loss & diabetes drugs, listen to my conversation with one of the pioneers in the field, Matthias Tschöp @helmholtz_munich.

Scroll down the page at the link below to hear “Obesity is a Brain Disease":

helmholtz-munich.de/en/helmhol

#scicomm #sciencepodcast #drugdevelopment #obesity #diabetes #metabolism #helmholtzpioneercampus

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1816 followers · 9693 posts · Server qoto.org

My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.

nature.com/articles/d41591-023

#immunology #alopecia #drugdiscovery #drugdevelopment

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1811 followers · 9623 posts · Server qoto.org

My new Clinical Pipeline column is out in Nature Medicine.

It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.

nature.com/articles/d41591-023

#immunology #drugdiscovery #drugdevelopment #alopecia

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1808 followers · 9599 posts · Server qoto.org

My new Clinical Pipeline column is out today in Nature Medicine, a look at JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.

nature.com/articles/d41591-023

#immunology #drugdiscovery #drugdevelopment #alopecia

Last updated 1 year ago

Tech news from Canada · @TechNews
884 followers · 23413 posts · Server mastodon.roitsystems.ca
Emiliano Sosa Barrios · @emiliano
34 followers · 90 posts · Server mastodon.uy
Thiago Carvalho · @cyrilpedia
1755 followers · 8814 posts · Server qoto.org

My latest Clinical Pipeline column for Nature Medicine: second generation anti-CD40L drugs for . A really cool story of deciphering the biology of adverse effects.

nature.com/articles/d41591-023

#autoimmunedisease #drugdevelopment #MonoclonalAntibodies #immunology #multiplesclerosis

Last updated 1 year ago

Uschi Symmons · @usymmons
112 followers · 62 posts · Server genomic.social

Following the global trend, India also passes amendment to remove from drug-trials and places a stronger emphasis on the ethical treatment of animals during trials

edtr.ai/duhc

#animals #3r #drugdevelopment

Last updated 1 year ago

Uschi Symmons · @usymmons
112 followers · 62 posts · Server genomic.social

Following the global trend, India also passes amendment to remove from drug-trials and places a stronger emphasis on the ethical treatment of animals during trials
edtr.ai/duhc

#animals #3r #drugdevelopment

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1702 followers · 8505 posts · Server qoto.org

If you're looking for a weekend podcast, here's a very interesting episode of Knowable on the placebo effect.

overcast.fm/+oWAyCyXD0?ref=the

#scicomm #drugdevelopment #placeboeffect

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1687 followers · 8206 posts · Server qoto.org

The trial is for idiopathic pulmonary fibrosis.

'The company said the drug, INS018_055, was the first entirely “AI-discovered and AI designed” drug to begin a phase 2 clinical trial and represented an important milestone for the industry.'

ft.com/content/82071cf2-f0da-4

#drugdiscovery #drugdevelopment #artificialintelligence

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1688 followers · 8193 posts · Server qoto.org

Last Thursday, the FDA voted to approve Sarepta's microdystrophin gene therapy for muscular .
fda.gov/news-events/press-anno

This was not an easy call, made on the basis of a biomarker rather than efficacy data. I wrote about it last month for Nature Medicine.

nature.com/articles/d41591-023

#duchenne #dystrophy #genetherapy #drugdiscovery #drugdevelopment

Last updated 1 year ago