Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a research assistant who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501807) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501807/research-assistant-i

If you have any questions, please email me at kt469@drexel.edu.
#autism #ASD #therapy #DrugDiscovery #ResearchAssistant #ResearchAssistantJob #AcademicJob #LabTechnician #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a postdoctoral researcher who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501741) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501741/postdoctoral-researcher

If you have any questions, please email me at kt469@drexel.edu.

#autism #ASD #therapy #DrugDiscovery #postdoc #PostdocJob #AcademicJob #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Crossing the Valley of Death

"In this Review, we quantify the discoveries that have been translated into approved therapies. While acknowledging the decades-long lag time between target identification and regulatory approval of derived therapeutics, we reasoned that addressing this question now is both legitimate and essential to guide future investments in the field."
#drugdiscovery #drugdevelopment #pharma

https://www.nature.com/articles/s41586-023-06388-8

Research Associate - University of British Columbia

University of British Columbia

Come join our team at #UBC in beautiful #Vancouver as a Research Associate to study #TB, #pathogens, #macrophages, #immunity, and #drugdiscovery!!

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-british-columbia-27778-research-associate/?feed_id=55439

#ScienceJobs #hiring #research ...
https://jobrxiv.org/job/university-of-british-columbia-27778-research-associate/?feed_id=55439

Drugs
Producing fast, unseen
Machines making artisinal
Aired molecules found in a breeze
AI-driven

#ai #drugdiscovery #antibodies #automation #cinquain #poetry

https://www.wired.com/story/labgenius-antibody-factory-machine-learning/

#introduction this is my conference tooting account. My regular account is https://scholar.social/egonw

I am a chemist working in biology on the domains of #cheminformatics and #bioinformatics (currently) on questions in the fields of #drugDiscovery, #metabolomics, and #toxicology I strongly support #openScience

My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
#Immunology #drugdiscovery #drugdevelopment #alopecia

https://www.nature.com/articles/d41591-023-00065-z

My new Clinical Pipeline column is out in Nature Medicine.

It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.

#Immunology #drugdiscovery #drugdevelopment #alopecia

https://www.nature.com/articles/d41591-023-00065-z

My new Clinical Pipeline column is out today in Nature Medicine, a look at JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.

#Immunology #drugdiscovery #drugdevelopment #alopecia

https://www.nature.com/articles/d41591-023-00065-z

The Onion: Worst Ways People Misuse Therapy Speak https://www.theonion.com/worst-ways-people-misuse-therapy-speak-1850637967 #obsessivecompulsivedisorder #medicinalchemistry #anxietydisorders #waltercronkite #drugdiscovery #jeffreydahmer #healthpolicy #therapy #mason #shit

New leads in the quest for better anti-trypanosome drugs
"We performed phenotypic screening against trypanosomes and identified a class of cyanotriazoles (CTs) with potent trypanocidal activity both in vitro and in mouse models of Chagas disease and HAT."
#InfectiousDisease #Chagas #drugdiscovery #trypanosome

https://www.science.org/doi/10.1126/science.adh0614

Latest blog post: Working with scaffolds in small molecules - manipulating SMILES strings with functions to read & query multiple SMILES. Many thanks to datamol, RDKit and several other great work with acknowledgements mentioned in post - https://jhylin.github.io/Data_in_life_blog/posts/14_Scaffolds_in_small_molecules/chembl_anti-inf_data_prep_current.html
#drugdiscovery #datamol #rdkit #compchem #cheminformatics

We showcased its use to explore a library of 1,600 #plant extracts in the frame of an antiparasitic #drugdiscovery project. The generated KG is publicly available, and you can test your own #SPARQL queries (or run the ones of the paper) here: https://enpkg.commons-lab.org/graphdb/sparql🔥

🌱 Preprint alert! 🌱

If you are a #NaturalProducts chemist using LC-MS/MS #metabolomics to unveil the secrets of Nature, we may have something for you: the Experimental Natural Products Knowledge Graph (#ENPKG)! 🌿

A small 🧵 based on Arnaud Gaudry's original LinkedIn post (https://www.linkedin.com/feed/update/urn:li:activity:7081613701270663168/)

#KnowledgeGraphs #ENPKG #SemanticWeb #OpenScience #DrugDiscovery

#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200

The trial is for idiopathic pulmonary fibrosis.

'The company said the drug, INS018_055, was the first entirely “AI-discovered and AI designed” drug to begin a phase 2 clinical trial and represented an important milestone for the industry.'
#drugdiscovery #drugdevelopment #artificialintelligence

https://www.ft.com/content/82071cf2-f0da-432b-b815-606d602871fc

Last Thursday, the FDA voted to approve Sarepta's microdystrophin gene therapy for #Duchenne muscular #dystrophy.
https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy

This was not an easy call, made on the basis of a biomarker rather than efficacy data. I wrote about it last month for Nature Medicine.

#genetherapy #drugdiscovery #drugdevelopment

https://www.nature.com/articles/d41591-023-00052-4

Postdoc Computer-Driven Drug Discovery Technologies

University of Southern California

Please join our team at Katritch lab to explore new directions in computer-driven #DrugDiscovery using structure-based and #DeepLearning approaches.

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-southern-california-27778-postdoc-computer-drive...
https://jobrxiv.org/job/university-of-southern-california-27778-postdoc-computer-driven-drug-discovery-technologies/?feed_id=48439

Boehringer moves forward with its glucagon/GLP-1 receptor dual agonist, survodutide.

"The German drugmaker is now preparing to launch a late-stage trial of its drug, which if approved, would compete with Eli Lilly’s Mounjaro and Novo Nordisk’s Wegovy. US pharma group Pfizer and biotech Regeneron are among the others hoping to enter the market."

#Metabolism #Pharma #DrugDevelopment #DrugDiscovery #Obesity

https://www.ft.com/content/d3f5e936-05af-4775-8247-cff1c007ba45

Targeting FGF21 and GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.
#drugdiscovery #drugdevelopment #metabolism #LiverDisease #FattyLiver #SciComm

https://www.nature.com/articles/d41591-023-00055-1