“She was given Antabuse to treat her alcoholism, but an autopsy upon her death (which was due to falling from a window, not cancer) revealed that her body was clinically cancer-free despite having no further cancer treatment.”

She fell from a window. 🤔

https://www.newsweek.com/cancer-treatment-drug-alcoholism-antabuse-742864

#disulfiram #CarbonDisulfide #DrugRepurposing #SideEffects

Serving customers, wrapping up REPO-TRIAL, starting REPO4EU: our ride from 2022 into 2023 https://www.hmpharmacon.com/h-m-pharma-consultancys-push-into-2023/ #drugrepurposing #clinicaltrials

There are nearly 7,000 known #RareDiseases and most of them have no cures. Repurposing existing drugs for rare diseases is fast becoming a viable strategy to fill this gap. For Labiotech, and thanks to a National Press Foundation grant, I write on a couple of #DrugRepurposing approaches for rare diseases. https://www.labiotech.eu/in-depth/drug-repurposing-viable-option-rare-disease-treatment/

#drugrepurposing: #lomitapide, a newly approved agent for the treatment of familial #hypercholesterinemia, inhibts the 'Notch pathway in triple-negative #breastcancer https://www.sciencedirect.com/science/article/abs/pii/S0898656822002911

Nature Medicine asked 11 leading researchers for their top clinical trials to watch in 2023. The replies include #exenatide in #Parkinsonsdisease - the most prominent and promising Phase III #drugrepurposing trial in recent years -, autologous CRISPR–Cas9-modified CD34+ human stem and progenitor cells for #sicklecelldisease; and there should be more substantial data on #lecanemab for #Alzheimers disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798349/

The #drugrepurposing group on LinkedIn ("Drug repurposing - reprofiling - repositioning") has 845 members: https://www.linkedin.com/groups/3705627/ Join the discussions! #pharmacology #drugdevelopment

This is my latest edited book about #covid19 #drugdevelopment . Herewith, we capture some ongoing trends in this area, including #drugrepurposing and others. You can download the chapters if you register into the system. Please kindly check it out here! 😊 🙂 https://www.intechopen.com/books/11690 @academicchatter @academicsunite

I do quarterly discussions of selected #drugrepurposing #patent applications for the Mary Ann Liebert journal, Assay & Drug Development Technologies. Here are the most recent ones, online in fulltext HTML for a brief period. https://www.liebertpub.com/doi/10.1089/adt.2022.097

Completed another Steering Committee videocall for our huge #REPO4EU #HorizonEurope project. We are building a generic #drugrepurposing framework for everybody to use. https://repo4.eu/

I did about a dozen freedom-to-operate analyses for #drugdevelopment in recent years, but it is only now that I compiled a point-by-point formal description and flowchart of how to best conduct the #patent search for a known compound in a new therapeutic indication -i.e., for #drugrepurposing. This is what having to write a Deliverable for a #HorizonEurope project such as #REPO4EU does for you.

I decided to make another account on the @med-mastodon.com instance so I can find more physician scientists there and post mainly on medical topics, including #psychiatry, #covid, #mentalHealth #drugRepurposing #fluvoxamineforCOVID19

I will also keep this account on @mstdn.social (will post in wide variety of topics there)
and my other one on @oslo.town (will post about various fun, humorous or interesting non-medical things her-

Spent almost the entire day chasing early (pre-millennium) successful (i.e., approved in truly new use) #drugrepurposing cases and integrating them in the #RepoScope database. Amazing how many there were.

General topics of clinical & research interest:
#psychiatry
#child-psychiatry
#ChildMentalHealth
#neurodevelopment
#autism
#ASD
#ADHD
#tics
#TouretteSyndrome
#Genetics
#Epidemiology
#WolframSyndrome
#ERstress
#Sigma1receptors
#SigmaReceptors
#DRD4
#RYRchannels
#RYR1
#RYR2
#RYR3
#COVID
#COVID19
#LongCOVID
#LongCovidisReal
#LongCOVIDtreatment
#LongCOVIDresearch
#fluvoxamineforCOVID19
#drugRepurposing