#Deer protected from deadly #disease by newly discovered #genetic differences

#EHD #epizootic #TLR3 #dsRNA #virus #mutation #evolution

https://phys.org/news/2023-02-deer-deadly-disease-newly-genetic.html

First-in-human application of double-stranded RNA #bacteriophage in the treatment of pulmonary #Pseudomonas aeruginosa infection -

#dsrna #phagetherapy

https://pubmed.ncbi.nlm.nih.gov/36636832/?utm_source=dlvr.it&utm_medium=twitter&utm_campaign=None&utm_content=12kswG5SFWVCwfirm5JCj21pS7ZfPHNIJmxYoRW1tSSTM88MJ2&fc=None&ff=20230113110624&v=2.17.9.post6%2086293ac

Replicating #chikungunya #virus, which occurs inside a 'spherule', apparently spends 80% of its time in the double-stranded #RNA intermediate state.

From the preprint:

"A first characterization of the filamentous material in the spherule indicated that each spherule contains a single copy of the viral genome, ~80% of which is present in #dsRNA form."
https://www.biorxiv.org/content/10.1101/2022.12.19.521029v1

Science Magazine (@sciencemagazine) First Release: Jean-Laurent Casanova & colleagues report that single-gene recessive inborn errors of OAS–RNase L pathway cause #myeloid cells to produce excess #inflammatory #cytokines following #dsRNA or #SARSCoV2 stimulation. This pathway may drive #MISC, a rare complication of #COVID19 in some #children!

https://bit.ly/Sci_abo3627

2/13
Now #dsRNA, unlike dsDNA, is inherently unstable and the two strands spontaneously separate to allow viral replication to continue.

In fact, they MUST separate for viral replication to continue.