John McBride (Seán Mac Giolla Bhríde) died on 5 May 1916 in Kilmainham Gaol. He was executed by the British for his participation in the 1916 Easter Rising in Dublin. McBride took part in the Second Boer War on the Boer side, for whom he raised the Irish Transvaal Brigade which became known as MacBride's Brigade. In 1903 he married Maud Gonne. The following year their son Seán MacBride was born.

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Francis Sheehy Skeffington, a pacifist, was murdered by the British forces on 26th April 1916 after being apprehended whilst trying to stop looting during the Easter Uprising. He was a friend and schoolmate of James Joyce and the real-life model for a character in Joyce's novel A Portrait of the Artist as a Young Man.

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The first victim of the Easter Rising, Margaret Keogh, was shot and killed by British soldiers while rushing to attend to patients and the wounded at the South Dublin Union (now the site of St James’s Hospital). 2/2

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On Easter Monday, 24th April 1916, the Easter Uprising (Éirí Amach na Cásca) began. The Irish Volunteers and Citizen Army seized the General Post Office (GPO) and several key buildings in Dublin and demanded Irish sovereignty. Pádraig Pearse read out the Proclamation of Independence at 12:04pm from the steps of the building after his men had seized the GPO.

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