I’m pleased to share our mini-preprint describing the work of a talented @BrownUniversity Leadership Alliance Student @nicole_jensenv who is at the University of Puerto Rico @uprarecibo

Nicole was mentored by senior Brown Pathobiology @BrownUPathoGP PhD student @carlsen_lindsey #eldeirylab @BrownPathology @BrownUCancer @BrownMedicine

miR-6883 downregulates HIF1α in colorectal and breast cancer cells

https://www.biorxiv.org/content/10.1101/2023.09.05.556385v1

Enjoyed meeting Amrendra K Ajay, PhD, Instructor at @harvardmed and @BrighamWomens and his colleagues during his visit to the Legorreta Cancer Center at Brown University this afternoon

We look forward to collaboration between #eldeirylab and Ajay’s new research program in areas of mutual interest involving fibrosis, TGF-beta, CDKi’s and cell cycle effects on the TME.

Interdisciplinary research collaboration leads to innovation.

It was a non-stop kind of day that started around 7 am this morning. I wasn’t planning on taking that picture from my office but had to when I got there and realized something was missing. Do you see it? #eldeirylab

The #eldeirylab celebrated Laura’s milestone birthday with gratitude for directing traffic, putting out fires, and juggling lots of activities @LauraKalafarski she even received a toy fire hydrant as a token of the appreciation
@ShiOnaCo @BrownUCancer @BrownUPathoGP @Attila_Seyhan @biocomicals @LanlanZhou @shengliang15 @tian_xiaobing @leiqing_zhang @tajiknia @Dina_rys @AshDoesResearch @carlsen_lindsey @PinhoSchwermann @alexmwong @ChristosCosteas

Great presentation by Brown University rising senior undergraduate student Connor Purcell at #eldeirylab meeting this morning of recent paper in @ScienceTM

NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates

https://www.science.org/doi/10.1126/scitranslmed.add1951

@BrownUCancer The Warren Alpert Medical School of Brown University

Pleased to share our latest review by @carlsen_lindsey and other #eldeirylab members at the Legorreta Cancer Center at Brown University @BrownUCancer @BrownUniversity @BrownMedicine on👇

The role of p53 in anti-tumor immunity and response to immunotherapy

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1148389

@shengliang15 @tian_xiaobing @andrewgeorge00 Taylor Arnoff

@rwsobol @SenduraiMani @SeanLawler20 @LiangChengMD @biocomicals @Attila_Seyhan @DawsonStemCell @bcarneiro7 @tajiknia

Pleased to share our most recent related manuscripts by undergraduates Brooke Verschleiser and William J MacDonald in #eldeirylab addressing TGF-beta mediated immune suppression including in MSS cancer. @BrownUCancer @BrownUniversity @BrownMedicine

https://e-century.us/files/ajcr/13/7/ajcr0148791.pdf

https://e-century.us/files/ajcr/13/7/ajcr0149917.pdf

Pleased to share William’s article featuring latest cancer therapeutics research from #eldeirylab @BrownUCancer @BrownUniversity @BrownMedicine

William J MacDonald, Brooke Verschleiser, Lindsey Carlsen, Kelsey E Huntington, Lanlan Zhou, Wafik S El-Deiry: Broad spectrum integrin inhibitor GLPG-0187 bypasses immune evasion in colorectal cancer by TGF-β signaling mediated downregulation of PD-L1. Am J Cancer Res 2023;13(7):2938-2947.

https://e-century.us/files/ajcr/13/7/ajcr0149917.pdf

Pleased to share Brooke’s article featuring latest cancer therapeutics research from #eldeirylab @BrownUCancer @BrownUniversity @BrownMedicine

Brooke Verschleiser, William MacDonald, Lindsey Carlsen, Kelsey E Huntington, Lanlan Zhou, Wafik S El-Deiry: Pan-integrin inhibitor GLPG-0187 promotes T-cell killing of mismatch repair-deficient colorectal cancer cells by suppression of SMAD/TGF-β signaling. Am J Cancer Res 2023;13(7):2878-2885

https://e-century.us/files/ajcr/13/7/ajcr0148791.pdf

It was a pleasure to host @BrownUniversity Leadership Alliance student @nicole_jensenv in the #eldeirylab this summer and observe excellent mentoring by senior @BrownUPathoGP @carlsen_lindsey

Nicole learned much and performed innovative experiments during her time in the lab @BrownUCancer @BrownMedicine @BrownPathology

She gave a great presentation at our lab meeting today and prepared a nice poster to describe her findings and future directions in two upcoming presentations.

Great presentation this morning by graduate student in @BrownUPathoGP Tyler Roady who presented a paradigm shifting article published a week ago in @Nature
This reshapes our understanding of the restriction point in the cell cycle and highlights a role for Rb family proteins p107 and p130. #eldeirylab @BrownUCancer @BrownUniversity @BrownMedicine

Happy to give a research update and career advice to students earlier today. I ended with a slide about work-life balance. #eldeirylab @BrownUCancer

Great presentation by Dr. Xiaobing Tian @tian_xiaobing of paper from Dr. Espinoza’s lab at University of Colorado showing novel insights into links between the p53 and ISR pathways and a novel synergistic combination that could be translated. #eldeirylab @BrownUCancer

https://www.nature.com/articles/s41467-022-35089-5.pdf

Very pleased to share this great paper (masterpiece) & highlight of Dr. Kelsey Huntington’s PhD thesis work in #eldeirylab @BrownUPathoGP @BrownUCancer @bcarneiro7 @AnnaLouieMD @LanlanZhou @Attila_Seyhan @drdonsdizon @DrSGraff

GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer

https://mdpi-res.com/d_attachment/ijms/ijms-24-10870/article_deploy/ijms-24-10870.pdf?version=1688046021

It’s an honor to spend some time welcoming cancer survivor, distinguished journalist, author of “The Truth in Small Doses: Why We’re Losing the War on Cancer—and How to Win It,” & past Editor-in-Chief of @FortuneMagazine @CliftonLeaf to Providence,Rhode Island, and looking forward to his visit at the Legorreta Cancer Center at Brown University @BrownUniversity @BrownMedicine @BrownHemOnc @BrownOncology @LifespanHlthSys @carenewengland @HasbroChildrens @Brown_SPH @VAProvidence #eldeirylab

Wishing Andrew George @andrewgeorge00 all the best as he embarks on the next phase of his career as a medical student in New Haven @YaleMed it’s been great having you as an #eldeirylab member the last 3 and a half years @BrownUCancer @BrownUniversity @brownmedicine

Spent some time on the bay with lab colleagues and collaborators #eldeirylab at The Warren Alpert Medical School of Brown University

https://www.facebook.com/100012528679052/posts/pfbid0znihcnX76KE1CHTTMWWgkAGyvPJKmFbhm1xYQgg87TzxDSFEPNko7gvY62TTamG8l/?mibextid=cr9u03

On my mind is harnessing but also taming the immune system in cancer therapy @BrownUCancer #eldeirylab

Delighted to have opportunity yesterday to speak with @GRASPtweets patient advocate mentors, #MBC survivors, oncologists & scientists about investigator-initiated trial @BrownOncology BrUOG 387 @BrownUCancer @BrownMedicine @BrownUniversity @LifespanHlthSys @carenewengland @OncoAlert
Our trial builds on >15 year effort in #eldeirylab first-in-human combo ER/PR+ Her2- breast cancer & tumors w/ Rb loss. Presented @ASCO #ASCO23 appreciate questions & discussion led by GRASP co-founder @itsnot_pink

Interesting as #eldeirylab identified TRAF4 as a p53 target gene 20 years ago

Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene

https://pubmed.ncbi.nlm.nih.gov/12788948/

@bcarneiro7