This new paper from Obashi and colleagues in the Taraska lab is very nice. It uses a FRET-CLEM approach to look at protein conformations in cells and tie those to ultrastructural correlates. Here they are looking at clathrin light chain dynamics relative to the clathrin cage during #endocytosis, but there are many other questions in cell biology where this could be applied.

https://doi.org/10.1038/s41467-023-36304-7

#CellBiology #StructuralBiology #ElectronMiscroscopy #MembraneTraffic