The EMBO Journal · @embojournal
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How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?
Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase
#encephalomyopathic #mtdna #mitochondrial #mitophagy #bnip3 #fbxl4 #Ubiquitin
Last updated 2 years ago