new research article:
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

https://doi.org/10.1016/j.celrep.2023.112593

"we verified the loss of B-type lamins inducing resurrection of ERVs as an initiating event of the aging-bound cascade in post-mitotic neurons. Of significance, these aging-related cellular and molecular changes can be alleviated by abacavir"

#Brain #Aging #HERV #EndogenousRetrovirus
#laminB

#EndogenousRetroVirus resurrection during ageing. As if we didn't have enough things to worry about already.
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RT @Lo_Zanzi
#LiveForever! @CellCellPress: #EndogenousRetroVirus (ERV) resurrection drives aging & inflammation via #STING! Retrovirus-like particles spread the aging-promoting effects to neighboring cells! A retrotrascriptase inhibitor drug protects from aging! http://doi.org/10.1016/j.cell.2022.12.017
https://twitter.com/Lo_Zanzi/status/1611847666480152580

RT @Lo_Zanzi@twitter.com

#LiveForever! @CellCellPress@twitter.com: #EndogenousRetroVirus (ERV) resurrection drives aging & inflammation via #STING! Retrovirus-like particles spread the aging-promoting effects to neighboring cells! A retrotrascriptase inhibitor drug protects from aging! http://doi.org/10.1016/j.cell.2022.12.017

🐦🔗: https://twitter.com/Lo_Zanzi/status/1611847666480152580

The Human Genome Is Full of Viruses #humangenome #viruses #endogenousretrovirus #erv
https://medium.com/medical-myths-and-models/the-human-genome-is-full-of-viruses-c18ba52ac195