CellBioNews · @cellbionews
73 followers · 1612 posts · Server scientificnetwork.deMolecular scissors caught in the act: Describing the function of #tRNA splicing #endonuclease #TSEN based on its structure.
https://phys.org/news/2023-07-molecular-scissors-caught-function-trna.html
The EMBO Journal · @embojournal
369 followers · 59 posts · Server sciencemastodon.com
What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage
#molecular #syntheticlethality #helicase #wrn #mismatchrepair #MMR #cancer #microsatellite #biochemcial #cruciform #dna #slx1 #slx4 #endonuclease
Vivek Mutalik · @vivek_mutalik
468 followers · 340 posts · Server fediscience.orgCells with stochastically increased #methyltransferase to #restriction #endonuclease ratio provide an entry for #bacteriophage into protected cell population -
#Phages #phage #bacteriophage #endonuclease #restriction #methyltransferase