PhD in Chromatin Biology

University College Dublin

#PhD position available at University College Dublin to work on the mechanisms of #enhancer dysregulation in acute myeloid #leukemia.

See the full job description on jobRxiv: https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768

#ScienceJobs #hiring #research #chromatin #transcription #enhancers #cance...
https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768

Postdoc opportunity at JGI with
Li Lei and John Vogel:

Using comparative genomics of polyploid grasses and plant engineering to identify and characterize cis-regulatory elements in plants.

https://jobs.lbl.gov/jobs/biological-sciences-postdoctoral-fellow-5890

#postdoc #plants #genomics #engineering #enhancers @LBNLBioSci

Hallo all - I guess an introduction might be a good idea!

I'm a mid-career (already!?) group leader, trying to unpick how different aspects of the local environment at #enhancers work together to regulate #transcription and #geneexpression.

We especially like non-coding enhancer #RNA, how their structures and dynamic movements make them functional; how disease mutations affect #eRNA activity and how the enhancer environment affects the #chromatin regulator CBP.

Super-excited to land here!

The Brachyury (a.k.a. "T") gene is critical for development of the notochord - the defining feature of chordates (yes, that includes YOU!)

But what turns Brachyury on in the notochord?

Check out this new preprint:
https://www.biorxiv.org/content/10.1101/2023.04.20.536761v1

@LBNLBioSci @berkeleylab #Brachyury #T #Enhancers #ShadowEnhancers

RT @IMPvienna
Research paper alert! The @stark_lab shows in @genomeresearch that the activity of #enhancers is encoded through a combination of their motifs’ identity & context. 👇🏽 (1/2)

News article: https://www.imp.ac.at/news/article/decoding-the-grammar-of-gene-regulation
Paper: https://genome.cshlp.org/content/early/2023/03/20/gr.277246.122.abstract?sid=2281e6bc-b8cd-4c4f-8802-ef4bdae173b9

RT @IMPvienna
Research paper alert! The @stark_lab shows in @genomeresearch that the activity of #enhancers is encoded through a combination of their motifs’ identity & context. 👇🏽 (1/2)

News article: https://www.imp.ac.at/news/article/decoding-the-grammar-of-gene-regulation
Paper: https://genome.cshlp.org/content/early/2023/03/20/gr.277246.122.abstract?sid=2281e6bc-b8cd-4c4f-8802-ef4bdae173b9

Research paper alert! The @stark_lab shows in @genomeresearch that the activity of #enhancers is encoded through a combination of their motifs’ identity & context. 👇🏽 (1/2)

News article: https://www.imp.ac.at/news/article/decoding-the-grammar-of-gene-regulation
Paper: https://genome.cshlp.org/content/early/2023/03/20/gr.277246.122.abstract?sid=2281e6bc-b8cd-4c4f-8802-ef4bdae173b9

#GeneRegulation digest #4:

🧬 New role of histone tails in nucleosome remodelling https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad079/7034407

🧬 TFBSs under accelerated #evolution in primates https://www.nature.com/articles/s41467-023-36421-3

🧬 Review of IDRs in #transcription regulators https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(23)00008-7

🧬 CpG islands & protection of genes from premature transcription termination https://www.nature.com/articles/s41467-023-36236-2

🧬 Regulation of #enhancers by DNA #methylation https://www.sciencedirect.com/science/article/pii/S1097276523000400

🧬 H2A-H2B & short-term memory of #chromatin states https://www.sciencedirect.com/science/article/pii/S0092867423000077

Happy to announce that our story on #DNAmethylation at #enhancers is out in
Molecular Cell! 👣🧬
https://doi.org/10.1016/j.molcel.2023.01.017
It was a fantastic PhD journey in the lab of @arnaud_kr @embl

➡️ Our study highlights the intricate relationship between DNA methylation and enhancer regulation and reveals that most enhancers are not instructed by 5mC. Yet, methyl-sensitive enhancers are highly dependent on TET activity.

1) Minimal promoter vectors🧬🐁

#Enhancers need a minimal promoter to drive transgenes.
To test regulatory elements, we have been using the mouse beta-globin minprom.

We coupled this tiny (129 bp!) promoter in Gateway pME vectors with fluorophores, creERT2, and Gal4.

3/n

RT @conwayer1@twitter.com

Still plenty of time left to apply for this @scienceirel@twitter.com funded post-doc fellow position in my group @UCD_Conway@twitter.com Please share and RT 🙏

#jobfairy #epigenetics #CancerResearch #phdlife #PhDone #enhancers #chromatin #polycomb https://twitter.com/conwayer1/status/1590753587776303104

🐦🔗: https://twitter.com/conwayer1/status/1602628608681558016

RT @robin_andersson@twitter.com

Our perspective on current challenges in understanding the role of enhancers in disease. @enhpathy_H2020@twitter.com @MSCActions@twitter.com https://www.nature.com/articles/s41594-022-00896-3 #enhancers #generegulation #enhanceropathies https://twitter.com/enhpathy_h2020/status/1600901519850835969

🐦🔗: https://twitter.com/robin_andersson/status/1600930605763825665

Our perspective on current challenges in understanding the role of enhancers in disease. @enhpathy_H2020@twitter.com @MSCActions@twitter.com https://www.nature.com/articles/s41594-022-00896-3 #enhancers #generegulation #enhanceropathies

📢 This is your chance to listen to Emma Farley @EKFarley (@UCSD) in person about regulatory principles governing #enhancers in development and disease. Attend our #DahlemColloquium!

📆 Dec 09, 2022, 1 pm CET
📍 @MPI_MolGen, Berlin
🔗 https://www.molgen.mpg.de/events/32999/3967453

@EliasFriman Congratulations Elias & team Bickmore past and present! Amazing stuff on #promoters, #enhancers & ulltra-longe range interactions w/o #cohensin and #polycomb across #mESCs, mammalian and other cell types- excellent tweetorial- you should covert to a tootorial here!

#paperoftheday

Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)

https://www.science.org/doi/10.1126/science.abn5647

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RT @PradeepMadapura@twitter.com

We just released a massively revised version of the paper. Overall, we show for the first time #LINE1 with #H4K16ac function as #enhancers to rewire the regulatory landscape of the genome https://www.biorxiv.org/content/10.1101/2022.04.29.488986v2 feedback welcome! https://twitter.com/PradeepMadapura/status/1520340222382329856

🐦🔗: https://twitter.com/PradeepMadapura/status/1593132480680562688

Hello. My name is Christopher Chase Bolt. Everyone calls me Chase. And this is my #ScienceMastadon introduction

I love #TranscriptionFactors and #Enhancers and their relationship to #GeneExpression. During my PhD at the #UniversityOfIllinois I studied the relationship between structural mutations in the genome and how they affect gene expression. #TissueCulture and #MouseGenetics n/n

Hello #ScienceMastodon Twitter refugees

#introduction I am a 🇫🇷 molecular & structural biologist working at the CNRS. I study the molecular mechanisms that control human gene expression focusing on #transcription factors & the Pol II machinery

Expect to see here a lot of info on #generegulation, #enhancers, #histone modifications & structural insights into the eukaryotic Transcription Initiation machinery. #CryoEM
I will also highlight #womeninscience to give them the visibility they deserve