I’m a retired allergist & agree w every word https://prospect.org/blogs-and-newsletters/tap/2023-08-07-eminent-domain-overpriced-drugs/

An #epinephrine auto-injector can be the difference between life or death. When needed a second dose is required often enough that guidelines recommend ALWAYS having 2 available… at $600 each! That’s a burden for many patients: Spending $1200 each yr or 2 (expiration dates!) for drugs they usually never use if they remain vigilant.

As the article says these are old tech & generic epinephrine. Criminal #pharma greed at work!

FDA To Approve First Epinephrine Nasal Spray:
Good news for parents of kids with severe food allergies and asthma. ARS Pharmaceuticals has developed a system for delivery of lifesaving doses of epinephrine via a nasal spray. #epinephrine #epipen #nasalspray #allergy #asthma
https://www.instagram.com/p/CviHuxTL89c/

I learned the hard way that U.S. airlines are not currently required to have EpiPens

"Anaphylaxis, a severe allergic reaction, is a life-threatening medical emergency and has to be treated with epinephrine as soon as possible. The glass vial of epinephrine planes carry is hard to use, and administering it safely involves multiple time-consuming steps that require medical knowledge."

#Anaphylaxis #allergies #epinephrine #EpiPens

https://www.statnews.com/2023/08/01/epipens-epinephrine-autoinjector-planes-airlines-faa/

At first I thought this was a followup to another story about an anaphylactic reaction during an airplane flight *last week*. No, it's a totally separate incident.

One patient had an expired epi-pen. The other had never had #anaphylaxis before.

Both planes had bottles of #epinephrine and a syringe, not an auto-injector. Fortunately there were doctors on both flights who knew how to properly fill and deliver a shot.

https://snacksafely.com/2023/04/physician-urges-faa-to-change-epinephrine-auto-injector-policy-after-mid-flight-anaphylactic-reaction/

#allergy #foodallergy

#EntomologyConsult: a patient develops hives, face swelling and hand swelling 40 minutes after being stung by a #yellowjacket. Should they be prescribed autoinjectable #epinephrine? My answer below. #venom #allergy #anaphylaxis

ok, like half of the useful non-antibiotic #ICU #drugs are apparently #UnapprovedByFDA

Source: #RaviGupta #JoeRoss in https://pubmed.ncbi.nlm.nih.gov/28944731/

#WTF
#atropine #epinephrine #hydrocodone #levothyroxine #morphine #nitroglycerine #oxycodone #pancrelipase #phenylephrine #vasopressin

#MedMastodon

Different people have different background levels of #dopamine. Excited, driven people have higher levels than mellower people.

#epinephrine and #dopamine tend to work together. Higher dopamine would make epinephrine feel like excitement, for example. They work together to lead you towards specific experiences.

Different people have different background levels of #dopamine. Excited, driven people have higher levels than mellower people.

#epinephrine and #dopamine tend to work together. Higher dopamine would make epinephrine feel like excitement, for example. They work together to lead you towards specific experiences.

RT from blues wireless (@blueswireless)

Introducing the #Epinephrine Climate-Aware Tracker, EpiCAT! Protect your loved ones & get peace of mind when it comes to your #EpiPen. Brought to you by @zfields in his latest @Hacksterio post: https://hubs.ly/Q01pJlhM0
#IoTforAll #IoTforGood

Original tweet : https://twitter.com/blueswireless/status/1583518478815752192

#Neurotransmitters

🧫 The synaptic terminal has these entities here, which are called synaptic vesicles, and they're small, little organelles.

🧫 They're little vesicles made of a membrane; just like the cell has a cell membrane, these vesicles have a vesicular membrane.
The neurotransmitters are within the vesicular membrane.

🧫 And, the neurotransmitter can be any number of a number of different molecules — #Glutamate, #GABA, #Serotonin, #Dopamine, #Acetylcholine, #Glycine, #Norepinephrine, #Epinephrine, #Histamine, #ATP.

🧫 The neurotransmitters are packaged in vesicles. The second thing that's important about this is that we can use the synthesis of a #neurotransmitter as a therapeutic tool.

🧫 So, for instance, Dopamine is missing in #ParkinsonsDisease.
It's not that dopamine isn't made per say, that's there's a problem with making it — it's that the cells that make it die.

🧫 There's something called 'Mass Effect', which means that you take the starting chemical (the substrate) and then through a series of enzymatic processes reaction, through a series of enzymatic reactions, we end up with a neurotransmitter.

🧫 In the case of Dopamine, what we do to treat in most people with Parkinson's is that we give them the substrate — and so that (drug) is what is commonly known as #Sinemet or #Parcopa.

🧫 So we flood the system with substrate, and the goal is to get a little bit of that neurotransmitter out of the system.

Image source: https://in.pinterest.com/pin/11962755239342046/?lp=true