'#Bioprospecting' technique uncovers #viruses that can kill deadly superbugs.

#phages #antimicrobial #epitopes #porin

https://phys.org/news/2023-05-bioprospecting-technique-uncovers-viruses-deadly.html

https://www.cell.com/cell/fulltext/S0092-8674(23)00403-8 “#BNT162b4 encodes variant-conserved, immunogenic segments of the #SARSCoV2 #nucleocapsid, membrane, and ORF1ab proteins, targeting diverse #HLA alleles. BNT162b4 elicits polyfunctional #CD4+ and #CD8+ #Tcell responses from diverse #epitopes in animal models, alone or when co-administered with BNT162b2 while preserving spike-specific immunity. Importantly, we demonstrate that BNT162b4 protects hamsters from severe disease and reduces viral titers”

New review from the Peters Lab at LJI: "T-cell epitope discovery and single-cell technologies to advance food allergy research"

As they write, "Advancements in single-cell T-cell receptor (TCR) sequencing in combination with transcriptome analysis provide exciting opportunities for identification and characterization of the TCR repertoires of allergen-specific T cells."

https://doi.org/10.1016/j.jaci.2022.10.025

#Tcells #FoodAllergy #Epitopes #Immunology #ImmuneSystem #CellularBiology #Genomics #OpenAccess

Hurray!

Eli Weinstein, @andrenguyen and myself got a contributed talk accepted at Winter Q-Bio! #winterqbio #qbio

Reach out if you'd like to hear about our work estimating the effects of mutations across the T cell receptor on epitope binding using observational data. The same sequence based methods generalize to a number of settings, including #antibodies.

#tcell #mutation #sequences #epitopes #epitopebinding #cdr #cdr3 #tcr #bcr

Anyone else headed to the conference in person?