The EMBO Journal · @embojournal
428 followers · 148 posts · Server sciencemastodon.com
#CircRNA CircPVT1 promotes ER-positive #breastcancer tumorigenesis and drug resistance by targeting #ESR1 and #MAVS
#circrna #breastcancer #esr1 #mavs
Lorenzo Gerratana · @LGerratana
24 followers · 12 posts · Server med-mastodon.comNew data supporting a deeper #ESR1 variant characterization in #BreastCancer. Y537S is resistant to #SERD #SERM due to stable conformation and activity. L536 shows varying sensitivity, greatest resistance: AZD9833 GDC-0810 RAD1901 #PrecisionMedicine #bcsm
#esr1 #breastcancer #serd #serm #precisionmedicine #bcsm
Lorenzo Gerratana · @LGerratana
22 followers · 10 posts · Server med-mastodon.com
#ESR1 mutations in the docking site of Selective Estrogen Receptor Degraders and Modulators #SERD differentially impact on drug affinity across agents. Integrating #ctDNA and #pharmacodynamics. #PrecisionMedicine #BreastCancer
#esr1 #serd #ctDNA #Pharmacodynamics #precisionmedicine #breastcancer