Looks like I will be going without estradiol for a few days. Delayed due to the process of getting changed over to the home delivery pharmacy covered under my Medicare Advantage plan. It's been a long time since I've had a gap. Should be fun, for certain values of fun. 🤷‍♀️

Hey, the good news is it's zero copay and zero shipping. And because of the overlap, I'll actually be about 60 days ahead on spiro. And I'll slowly build back a cushion on E too.

#trans #transgender #estradiol #estrogen #meds

Injection of the week is done so is Bottle 3. #estradiolvalrate #estradiol

N.B.,

It's worth hopping on to this that only #testosterone affects one's voice.

So, while voice will naturally deepen to varying degrees for trans mascs, #estradiol cannot affect voice at all for trans fems.

Whenever you hear a trans fem person with a more-feminine voice, that's usually all entirely through voice training / therapy, as only a handful of folks can afford #VocalFeminisationSurgery (#VFS).

'Life At 6mg'

(Older photo of mine)

#DSLR #Photograph #Photography #Transgender #Trans #Estrogen #Estradiol

@Flyingfirepig In case it helps further, estradiol levels during pregnancy levels can rise up to 20,000 pg/mL: which is over 73,000 pmol/L!!!

As such, I wouldn't worry if your estradiol levels reach a few thousand pmol/L during feminising HRT.

#estradiol #HRT #trans #transgender #TransFem #DIYHRT

@Impossible_PhD Thanks for the balanced view! Especially this:

"You remember back in the 1990’s, when there was that big panic over women’s HRT, when we found out they could cause blood clots? and in the 1970’s, when we found that if it was too old it could cause cancer? All of that came from a combination of drugs called Premarin and Medroxyprogesterone.

We don’t use that stuff anymore, because it is horrible."

Sad how many women, and health professionals, are still stuck there!

#estradiol

Jak ja się cieszę, że opakowanie estrofemu kosztuje 4,80 PLN

#estruś #estradiol #hrt #mtf

@AngryTransLady I'm a lot luckier than most in many ways, so I really shouldn't complain about my own situation 😞 But yeah, NHS England is awful for trans care.

FWIW, a year's supply of estradiol enanthate from a highly-trusted DIY pharmacy costs under $100 USD.

https://otkph.com/product/estradiol-enanthate/

Their vials have been tested, along with others.

https://transharmreduction.org/hrt-testing

#trans #TransFem #DIYHRT #HRT #estradiol

today ill be moving from pills to injections, and i am super excited! #estradiol #hrt #transfemme

This is entirely for survey purposes, but I've heard there's no study done on this so I want to see what trans people, taking feminising hormones, experience. I am just looking for data points and possibly encourage a study if there's a significant amount of people answering, so please boost this. #study #poll #OpenSource #science #boost #trans #estradiol #estrogen #AntiAndrogen #progesterone #hrt #enby

If you are trans, AMAB, and take feminizing hormones do you experience any of these?

In the past two months I've had three medication changes.
I've gone from #Adderall XR for my #ADHD to #Strattera / #Atomoxetine which has made my #insomnia worse and isn't providing as much benefit as Adderall did (but the Adderall was making me bitchy and, since I didn't take it on weekends, worthless on weekends where I'd just sleep). It also makes me extremely constipated.
I've switched from #medroxyprogesterone to just #progesterone which seemed to improve my mood but made me a bit more emotional.
Then I just switched from oral #estradiol to once weekly injections.

I feel like crap. My emotions are a garbage fire on a roller coaster, I have trouble falling asleep and staying asleep (I'm not sure if I'm getting to REM when I am asleep), I get so sleepy during the day that it effects my ability to do my job. My stomach hurts and I've gained about 10 pounds.
Also seasonal allergies so my throat hurts from all the drainage.

That's it. I just wanted to rant to Internet strangers.

I'm on vacation next week which I desperately need. We aren't traveling or doing anything special. My birthday and my wife's birthday are both next week.
We don't travel because there is still a pandemic and she's high risk.

My friends: there’s more than one way to give your daily medication that extra something! Meet #Oestrogel or #estradiol Henge! Posted on Twitter by @SandySteeley https://twitter.com/sandysteeley/status/1627711118096363520 #Stonehenge #estrogen

I usually don’t post Stonehenges to my personal account but since I have friends for whom this is a special interest I will share this one: #Oestrogel or #Estradiol Henge. There’s more than one way to give your daily #estrogen that extra something! #Stonehenge
From @SandySteeley on Twitter. https://twitter.com/sandysteeley/status/1627711118096363520

I usually don’t post Stonehenges to my personal account but since I have friends for whom this is a special interest I will share this one: #Oestrogel or #Estradiol Henge. There’s more than one way to give your daily #estrogen that extra something! #Stonehenge
From @SandySteeley on Twitter. https://twitter.com/sandysteeley/status/1627711118096363520

for those of you who have switched from pills to injections did you experience noticeable changes? i am thinking about switching, i have been on pills for the last 5 months. thanks.

#hrt #estradiol #transwoman #hormones

@nadel
"Perhaps now would be a reasonable time to raise questions brought up by the personal histories published so far."

I appreciate the invitation! I'm still thinking about this bit of the Gyuri Buzsaki episode:

"What make the hippocampus special is the granule cell. There is no such cell type in the neocortex. Granule cells keep dividing postnatally and the only cell type known whose life depends on circulating hormones (steroids)."

I've found a few interesting links, including:

Estrogen modulates place learning through estrogen receptors in the hippocampus - Lilia Zurkovsky 2006
(Where they implanted the hormones directly into the rat hippocampus...)

Estrogen Receptors, the Hippocampus, and Memory - Linda A. Bean 2014
(Where they used receptor knockout mice and viral vector delivery of different estrogen receptors to modify the sensitivity to estrogen.)

Do you know of anyone studying this in humans? I guess it would be difficult, since as I (barely and maybe wrongly) understand things, our estradiol level above the blood-brain barrier is higher and poorly correlated with the testable levels circulating below there. And hippocampal E2 is mostly created in the hippocampus itself...

Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids - Yasushi Hojo 2018
https://www.frontiersin.org/articles/10.3389/fendo.2018.00183/full

"Penetration of plasma E2 into the hippocampus, however, is not able to account for the level of hippocampal E2 because hippocampal E2 is much higher than that in plasma."

This graphic is fascinating:
https://www.frontiersin.org/files/Articles/357380/fendo-09-00183-HTML-r1/image_m/fendo-09-00183-g001.jpg

Would love to hear anyone's thoughts on the influence of estrogen on spatial awareness and memory!

#hippocampus #estrogen #estradiol #neurosteroids #biosynthesis #GranuleCell

Second puberty is officially on its way! Stuck my first #Estradiol patch on my body yesterday. Interestingly, the leaflet didn't mention use of the patches by #trans people at all, nor did it mention long-term use. From A to Z, it was all about cis women using the patches for a short period to correct a hormonal imbalance. Like, do #transfeminine people even exist for the medical world?

New #estradiol record! Take that, 500-700 pmol/L target range! I will go boldly into uncharted territory with not-normally-seen-even-during-pregnancy levels!

Has anyone else been having issues with their #estradiol patches coming off? I am having to tape mine down constantly. This current patch lasted one day before it started coming off

It's starting to stress me the hell out.

Ironically, it didn't even occur to me that I was having periods until the cis women and transmasculine people in my life suggested it as a possible explanation for my symptoms. 5/5

#trans #transgender #transsexual #transfeminine #transwomen #transwoman #transgirls #transgirl #hrt #hormones #hormonereplacementtherapy #estradiol #estrogen #transmisogyny #transition #medicaltransition #periods