Such a cool system. A fun project to work on. First DMI in maize I believe. And cool meiotic drive, sRNA, and teosinte introgression. #EvolgenPaper https://www.biorxiv.org/content/10.1101/2023.07.12.548689v1

Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper

Neat new #EvolgenPaper by @gvbarroso.

The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation:

https://peercommunityjournal.org/articles/10.24072/pcjournal.267/

Excited to sit down with this one!

Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10

Out today in PNAS: "The paradox of adaptive trait clines with nonclinal patterns in the underlying genes" https://www.pnas.org/doi/full/10.1073/pnas.2220313120 This study shows that under complex multivariate adaptation, trait clines can evolve despite nonmonotonic allele frequency patterns across environmental gradients. These patterns are not discovered by genotype–environment association methods, which are widely used to discover adaptation. #EvolutionPaper #EcoEvo #SLiM #Genetics #Genomics #EvolgenPaper #PopGen

Our latest #preprint develops a new metric of #CodonAdaptation (not just #CodonBias) to measure the kind of #EffectivePopulationSize that matters to #NearlyNeutralTheory, and uses it to discover that #NaturalSelection prefers high #IntrinsicStructuralDisorder https://www.biorxiv.org/content/10.1101/2023.03.02.530449v1 1/6
#MolecularEvolution #PopulationGenetics #EvolgenPaper

New preprint by
Carl Veller and myself on the interpretation of population and family-based genome-wide association studies in the presence of confounding

https://www.biorxiv.org/content/10.1101/2023.02.26.530052v1

#GWAS interpretation is tricky, for three broad reasons: indirect effects of relatives, genetic confounding, and environmental confounding—where genetic confounding (long-distance LD) arises due to population structure, assortative mating, and selection. #EvolgenPaper

Recently we also evaluated how well a widely-used method called "gradient forests" performs for the estimation of "genomic vulnerability". In this paper we highlight some strengths and weaknesses of the approach. Notably, genetic drift can cause small populations to have large "offset" values, highlighting issues with current interpretations and estimations. #EvolutionPaper #Evolution #EvolGenPaper https://onlinelibrary.wiley.com/doi/10.1111/eva.13354

In our recent "Inversion Invasions" paper we studied the conditions under which inversions invade genomes and become involved in adaptation. We found that inversions were more likely to be involved in adaptation when the genetic basis of the adaptive trait was highly polygenic. #EvolgenPaper #EvolutionPaper #PopulationGenetics @royalsociety https://royalsocietypublishing.org/doi/10.1098/rstb.2021.0200 We developed this plot to visualize how inversions capture and gain genetic variation through time.

Runs of homozygosity reveal past bottlenecks and contemporary inbreeding across diverging populations of an island colonising bird - Martin - Molecular Ecology
https://onlinelibrary.wiley.com/doi/abs/10.1111/mec.16865

#EvolgenPaper
#populationgenetic

Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5

#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper

Cool #preprint of #EvolutionaryBiology by Bohutínská et al: "Repeated adaptation to whole genome duplication in outcrossing Arabidopsis is mediated by mosaic adaptive haplotypes" #EvolgenPaper
https://www.biorxiv.org/content/10.1101/2023.01.11.523565v1

These were later updated to be #EvolgenPaper #EvolutionPaper [and remember the internal caps] to avoid the underscores.

#EvolgenPaper Synchronous effective population size changes and genetic stability of forest trees through glacial cycles https://www.biorxiv.org/content/10.1101/2023.01.05.522822v1

@rspfau @jrossibarra @kevinrthornton @alxsim #EvolgenPaper #EvolutionPaper

Updated perspective piece on why human genetics should move away from using "genetic ancestry" groups as a sample description.

https://arxiv.org/abs/2207.11595

#EvolgenPaper #EvolutionPaper

recirculating to start using hashtags

OK sounds like #EvolgenPaper is good hashtag for adding to toots and threads on Evolutionary and Population Genetics papers

We could use #EvolutionPaper for papers more generally associated with Evolutionary Biology.

Please RT this and consider using these for tooting about papers, your own of those of others. That way we'll be able to keep track of them all more.

We could also use #evolution_paper for the broader field. Open to other suggestions, eg if #EvolgenPaper #EvolutionPaper is easier (though if folks forget the caps they are less accessible).