Nature Medicine asked 11 leading researchers for their top clinical trials to watch in 2023. The replies include #exenatide in #Parkinsonsdisease - the most prominent and promising Phase III #drugrepurposing trial in recent years -, autologous CRISPR–Cas9-modified CD34+ human stem and progenitor cells for #sicklecelldisease; and there should be more substantial data on #lecanemab for #Alzheimers disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798349/