We found that the #Parkinson's disease related kinase #LRRK2 interacts with vesicular #SNAREs #VAMP4 and #VAMP7. #VAMP4 and #VAMP7 are required for proper processing and release of #Parkinson's disease #biomarkers #VGF as we found using #secretomics. We found late endosomal #secretion of #VGF together with #exosome markers like #CD63. We also developed a #rushassay to study #VGF #trafficking.
#parkinson #lrrk2 #snares #vamp4 #VAMP7 #biomarkers #vgf #secretomics #secretion #exosome #cd63 #rushassay #trafficking
Cell Encapsulator made as PLLA/PLGA (50:50) electrospun porous (750 nm) scaffold
⏫👤Cardiac mesenchymal cell survival (1 mo in vivo) & #Exosome secretion
Implanted locally->⏫🐭#Limbischemia & #MyocardialInfarction
Dr. David Lundy lab J Controlled Release 2022
https://www.sciencedirect.com/science/article/pii/S0168365922007350
#Limbischemia #exosome #MyocardialInfarction
Referenced link: https://phys.org/news/2022-09-key-factor-exosome-mediated-viral-transmission.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-09-key-factor-exosome-mediated-viral-transmission.html
Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1566777337508773889#m
Researchers identify key factor in #exosome-mediated viral #transmission from insects to plants @PNASNews https://pnas.org/doi/full/10.1073/pnas.2207848119 https://phys.org/news/2022-09-key-factor-exosome-mediated-viral-transmission.html