Another addition to the toolbox: between #organoids and #explantmodels are the #epitheloids ...self maintaining over a long time, these models recapitulate epithelial structures. #ModelSystem #models #bioengineering #tissue #tissueengineering @schumacher @gpollara
https://www.biorxiv.org/content/10.1101/2023.01.03.522589v1.full

An #assembloid -like model system was used in a cohort of #breastcancer patients to test the utility in #treatments selection...with interesting results, putting approaches with #organoids and #explantmodels in #Oncology to the test for #stratification and #PersonalizedMedicine
@gpollara @cyrilpedia
https://www.pnas.org/doi/10.1073/pnas.2209856120

Building blocks made from living cells...an emergent therapeutic strategy. We still have to find the "treasure chest" of suitable targets and the right order of intervention... #bioengineering #cellulartherapies #tissueengineering #organoids #explantmodels #immunology
https://scim.ag/Xu

@gpollara @schumacher thanks for sharing! really excellent work and also brillant to adress this complicated immunological regulation in this specific disease situation.
What really is an advantage of #explantmodels is their excellent comparability to the corresponding human situation (aka "translatability"): https://pubmed.ncbi.nlm.nih.gov/27070705/

@schumacher @gpollara And in addition to organoid systems one can consider #explantmodels that contain the full spectrum of human cells, so you have complexity at the cost of more challenging interventions to test hypotheses ...

@tonic In addition one could think about going fully human for more insights: #explantmodels could allow factor identification or deliver modulating supernatant...
https://pubmed.ncbi.nlm.nih.gov/27070705/

An alternative to #organoids for new #cellulartherapeutics are #explantmodels that guide approaches to overcome resistance mechanisms...an example #Immunotherapy #pancreaticcancer #biotechnology https://www.nature.com/articles/s41551-021-00737-6