Folded membrane microdomains between the cuticle and epidermis called 'meisosomes' have a role in maintaining and patterning these structures in #CElegans. and its connection with the #ExtracellularMatrix. https://elifesciences.org/articles/75906?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Amazing to watch the collaborative lab effort, including @lankylaste @BesaizSanchez. And a special shoutout to @C_M_Hobson at @AICjanelia for their invaluable help acquiring the lattice light-sheet movies
#ExtracellularMatrix #Drosophila #DevBio

Through the eyes of an #osteocyte. In #bone, this is what the environment of partially embedded osteocytes (osteoblastic–osteocytes) is like!

Scanning electron microscopy has been used to observe the orientation of mineral platelets in relation to osteoblastic–osteocyte lacunae on the surface of deproteinized trabecular bone in adult sheep.

Read more:
https://doi.org/10.1007/s00223-015-0072-8

@zeiss_micro #microscopy #biology #imaging #biomineralization #extracellularmatrix #friday

👉 During development, #Netrin1 is released and diffusible in the microenvironment. This study shows that in #cancer, #Netrin1 accumulates in the #ExtracellularMatrix. The authors used this property to follow its in vivo accumulation by radiolabeling and to target netrin-1-expressing tumor cells with #radioimmunotherapy.

By D. Kryza, P. Mehlen, D. Sarrut, B. Gibert & colleagues

Full #openaccess article 🗞️ : https://doi.org/10.15252/emmm.202216732

@Oncologiavet

Looks interesting
#2BadItsPaywalled

#ExtracellularMatrix

@biorxivpreprint

^ new preprint, senior author is Berenice Benayoun

#SexDifferences #immunology
#ExtracellularMatrix

RT @WickstromLab
Join us tomorrow, Tue 28th for some exciting science on #integrins and the #extracellularmatrix https://twitter.com/DGZ_info/status/1629921420305113090

Great review from Nicola Stevenson. Part of our team in Biochemistry at the U of Bristol researching #Golgi #cilia and #extracellularmatrix

https://journals.biologists.com/bio/article/12/2/bio059719/287059/The-factory-the-antenna-and-the-scaffold-the-three

Part of Biology Open's series of Future Leader Reviews. @BiologyOpen

Nikki is making great progress on our @BBSRC sLoLa.
This review includes some thoughts beyond her current work towards more integration with cilia biology.

new Sheeky Science Show video

'Healing tissue from the inside out - infusible biomaterial'

discusses article:
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues
https://doi.org/10.1038/s41551-022-00964-5

https://youtu.be/fMGlmUSACaQ

#science #medicine #ExtracellularMatrix #biomaterials #videos

Very very cool. I had a crack at this pre-resolution revolution, couldn't quite get it to fly, and moved on to other things.

Good to see that the biochemistry all lines up nicely with the structure.

"Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies"

#CryoEM #StructuralBiology @strucbio #Science #Research #ExtracellularMatrix
https://www.nature.com/articles/s41467-023-36077-z

Preprint 🚨

Full-length αIIbβ3 #CryoEM structure reveals intact integrin initiate-activation intrinsic architecture

#StructuralBiology @strucbio
#ExtracellularMatrix #Research
http://biorxiv.org/cgi/content/short/2022.12.19.520944v1?rss=1

#introduction:
We are a new cell systems biology team at the #UniversityOfManchester #UoM.
We study #CellAdhesion #networks in health and disease, especially #cancer.
Fascinated by how adhesion proteins help #cells function in so many ways!

#proteomics #integrins #adhesion #cytoskeleton #nucleus #bioinformatics #omics #ExtracellularMatrix #ECM #NetworkBiology #DataViz