In issue 13:
Highlight on #FBXL4 E3 controlling basal mitophagy via NIX/#BNIP3 degradation
#Salicylic acid attenuates #brassinosteroid signaling by removing S-acylation from proteins
#Nucleoporin foci as stress-sensitive condensates
Mechanism of #botulinum #neurotoxin presynaptic targeting
Cover: Natalia Prevarskaya and coworkers
https://www.embopress.org/toc/14602075/2023/42/13

What controls basal, #Parkin-independent #mitophagy?

E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively

https://www.embopress.org/doi/10.15252/embj.2022112799

How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?

Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase

https://www.embopress.org/doi/10.15252/embj.2022113033