Hola Titánicos, cada 8 de septiembre se celebra el día Mundial de la Fibrosis Quística, para visibilizar a esta enfermedad rara que afecta a 72.000 personas en el mundo.

https://somosdisca.es/dia-mundial-de-la-fibrosis-quistica-2023/

#fibrosis #fibrosisquisitica #pulmones #enfermedadrespiratoria #enfermedadpulmonar #dificultadrespiratoria #salud #discapacidad #disability #disabilities #somosdisca #gentetitanica #visibilidad #prevencion

Postdoctoral Researcher (all genders) Fibrosis and Wound Healing @BioMed_X

The BioMed X Institute is establishing a new, fully funded research group at its new XSeed Labs incubator.

https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-fibrosis-and-wound-healing/?feed_id=44478

#ScienceJobs #job #fibrosis #woundhealin...
https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-fibrosis-and-wound-healing/?feed_id=44478

Postdoctoral Researcher (all genders) Fibrosis and Wound Healing @BioMed_X

The BioMed X Institute is establishing a new, fully funded research group at its new XSeed Labs incubator.

https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-fibrosis-and-wound-healing/?feed_id=43758

#ScienceJobs #job #fibrosis #woundhealin...
https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-fibrosis-and-wound-healing/?feed_id=43758

Referenced link: https://medicalxpress.com/news/2023-04-reveals-mechanism-circadian-clock-molecule.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-04-reveals-mechanism-circadian-clock-molecule.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1647995608689528833#m

RT by @physorg_com: Study reveals mechanism by which a circadian clock molecule leads to #lung #fibrosis @NatureComms https://www.nature.com/articles/s41467-023-36896-0 https://medicalxpress.com/news/2023-04-reveals-mechanism-circadian-clock-molecule.html

New @SciImmunology research involving patient and mouse samples unveils 5 protein markers on macrophages suspected to drive #fibrosis in the lungs and liver. https://scim.ag/2eZ #press

IL-11 as a therapeutic target for lung #Fibrosis #Emphysema in #MarfanSyndrome

In Marfan🐭🫁, IL11-GFP reporter is active in #EndothelialCell #SmoothMuscleCell Fibroblast but not alveolar epithelia

Dr. Stuart A Cook & Wei Wen Lim lab ATVB 2023
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318802

Also don't miss the story on IL-11 as mediator of Mafan #Aortopathy from Circ Res 2022

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.320381

Referenced link: https://medicalxpress.com/news/2023-03-protein-fibrosis-death-spiral.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-protein-fibrosis-death-spiral.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1638544732694487041#m

RT by @physorg_com: The single protein that causes the #fibrosis death spiral @NatureComms https://www.nature.com/articles/s41467-023-36189-6 https://medicalxpress.com/news/2023-03-protein-fibrosis-death-spiral.html

✨NEW PAPER✨Imagine you’ve got a piece of plastic stuck in your stomach - stabbing, poking, and prodding constantly. Besides being incredibly uncomfortable, what would that do to your delicate internal tissues?
One of our #AdriftLab Honours students (Hayley) has just published her first, first-author paper in the Journal of Hazardous Materials, investigating the effect that #PlasticIngestion has on the formation of scar tissue within the stomach of #seabirds from #LordHoweIsland. While scar tissue formation is a natural part of the healing process, excessive scarring can impact tissue function and cause disease, known as #fibrosis #OpenAccess paper here ➡️ sciencedirect.com/science/arti...
We found plastic ingestion was significantly related to severe, organ-wide scar tissue formation in the stomach, with some birds exhibiting a near-complete loss of tissue structure (photo panel on LEFT: collagen/scar tissue has stained blue). This is the first time plastic-related scar tissue formation has been documented in wild animals, but what we could see was so severe that it also led us to propose a new disease, #Plasticosis – fibrosis as a result of plastic.
As >1200 species are already documented to ingest plastic across both aquatic and terrestrial environments (including us!), our findings have major implications.
#WomenInSTEM #seabirds #PlasticPollution #SubLethalEffects #Microplastics #Nanoplastics #silicosis @SeabirdSentinel @TheLabAndField

✨New paper alert✨Imagine you’ve got a piece of plastic stuck in your stomach - stabbing, poking, and prodding constantly. Besides being incredibly uncomfortable, what would that do to your delicate internal tissues?

One of our #AdriftLab Honours students (Hayley) has just published her first, first-author paper in the Journal of Hazardous Materials, investigating the effect that #PlasticIngestion has on the formation of scar tissue within the stomach of #seabirds from #LordHoweIsland. While scar tissue formation is a natural part of the healing process, excessive scarring can impact tissue function and cause disease, known as #fibrosis #OpenAccess paper here ➡️ https://www.sciencedirect.com/science/article/abs/pii/S0304389423003722

We found plastic ingestion was significantly related to severe, organ-wide scar tissue formation in the stomach, with some birds exhibiting a near-complete loss of tissue structure (photo panel on LEFT: collagen/scar tissue has stained blue). This is the first time plastic-related scar tissue formation has been documented in wild animals, but what we could see was so severe that it also led us to propose a new disease, #Plasticosis – fibrosis as a result of plastic.

As >1200 species are already documented to ingest plastic across both aquatic and terrestrial environments (including us!), our findings have major implications.
#WomenInSTEM #seabirds #PlasticPollution #SubLethalEffects #Microplastics #Nanoplastics #silicosis

a new #experimental #antibody #therapy for #endometriosis that has not yet been tested in humans, but has shown promising results in animal studies. The #therapy, called AMY109, is an #antibody that binds to and blocks a signaling molecule called #interleukin-8 (IL-8) that is associated with #inflammation in #endometriosis, and when tested in monkeys, it was found to reduce the size of #lesions and #fibrosis.

https://www.sciencealert.com/experimental-surgery-free-treatment-shrinks-endometriosis-lesions-in-animals

RT @KonradHoeft
We are so thrilled to see our new study out in @CellReports today (https://bit.ly/3XJ5MXB)! We investigated #platelet-#macrophage-crosstalk in #fibrosis identifying a platelet-instructed SPP1 macrophage subset that controls fibroblast activation. 1/11

Eric Leif Sander et al

december 2021

#SarsCov2 infection triggers profibrotic #macrophage responses & lung #fibrosis

https://doi.org/10.1016/j.cell.2021.11.033

Just Published!

SIRT3 and Cutaneous Cancers

https://link.springer.com/chapter/10.1007/16833_2022_109

#Cancer #CancerResearch #Fibrosis #Mitochondria

Exciting #NASH story from our #Liver advisor Scott Friedman's lab out in Science Translational Medicine, with @GordianBio playing a small #CompBio role 🎉

Sammi identified new stellate cell behavior to help explain #fibrosis progression, genetic pathways and interventions, 🐭&🧑‍🦰 #singlecell data, paper has it all!

https://www.science.org/doi/10.1126/scitranslmed.add3949

Recently Published!

The Tumor Microenvironment in Hepatocellular Carcinoma

https://link.springer.com/chapter/10.1007/16833_2022_66

#Cancer #CancerResearch #ImmunoTherapy #Immunology #Microenvironment #Fibrosis

RT @TaNaishaJ@twitter.com

11/11 "Poor #dental #health increases the risk of a #bacterial #infection in the #blood #stream, which can affect the #heart #valves."

#SARSCoV2 induced #periodontal #fibrosis and correlated #atrial #fibrillation (#AF)

https://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/heart-disease-prevention/faq-20057986

https://www.tctmd.com/news/atrial-fibrosis-mediated-gum-disease-may-be-missing-af-link

This is a powerful feature about a #Newfoundland #mining town left with #contamination after an #asbestos #mine operated & closed there. Quote from article: "The prospect of long-term exposure to free-floating asbestos, over the last half-century, still hangs over the town today, Philpott says. Most people want it gone. Many fear they’re still breathing in what killed their parents, their neighbours." https://www.cbc.ca/newsinteractives/features/toxic-towns-baie-verte #toxic #tailings #cancer #lungdisease #fibrosis

#Fibrosis ILB®, Low Molecular Weight #Dextran Sulfate (LMW-DS) Shows #Anti-Fibrotic Effects in Pre-Clinical Trial | #Fibrotic #diseases are known to affect several vital organs in the body and are a major cause of mortality and morbidity. There has been a little success in treatment of these diseases so far. ILB®, the Low Molecular Weight Dextran Sulfate (LMW-DS) has shown promising results in a pre-clinical trial...

https://www.scientificeuropean.co.uk/medicine/fibrosis-ilb-low-molecular-weight-dextran-sulfate-lmw-ds-shows-anti-fibrotic-effects-in-pre-clinical-trial/

RT @Brunorm84@twitter.com

Spatial molecular and cellular determinants of #STAT3 activation in liver #fibrosis progression in #NAFLD @JHEP_Reports@twitter.com https://www.jhep-reports.eu/article/S2589-5559(22)00200-2/fulltext

🐦🔗: https://twitter.com/Brunorm84/status/1595487269632327680

Tissue, Matrix and Pathobiology 2023, a joint meeting this October from ASIP, HCS and ASMB

Topics include #liver, #lung and #kidney #fibrosis, #cancer #metastasis, #inflammation, #cardiovascular #disease, #development, #neuropathology, #proteoglycans, #cell #junctions, #sphingolipids, #tissue #clearing, and more!