New NIOO publication: The Fitness of Beta-Lactamase Mutants Depends Nonlinearly on Resistance Level at Sublethal Antibiotic Concentrations. #fitnesslandscape #filamentation #cefotaxime #antibiotics #lactamase
https://doi.org/10.1128/mbio.00098-23

'An important aspect of this study is that we inferred the fitness landscape based on antibiotic resistance profiles and not genotypes. Although previous studies have focused on constructing fitness landscapes based on mutations for a few genes [4,6], because the number of possible genotype changes (e.g., nucleotide changes) associated with antibiotic resistance evolution is immense [32], empirical fitness landscapes based on genotypes were not capable of predicting/controlling evolution.'

#Evolution #EvolutionaryBiology #antibioticresistance #FitnessLandscape @PLOSBiology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001920#sec008

New paper: How development affects evolution @journal_evo

https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpac003/6955321

#evolution #development #evodevo #Gmatrix #mathbio #plasticity #developmentalbias #nicheconstruction #extrageneticinheritance #senescence #ageing #evolutionarydynamics #adaptivedynamics #fitnesslandscape

How is diversity maintained in a competitive arena (be it Darwinian or political), when intuitively one would expect a single optimal strategy to succeed over all others? In simulations, stable clusters occur when there is an advantage to being different per se. Such models could explain #SexualDimorphism, #ImmunogeneticVariation, or even #PoliticalParties. But confirming this empirically is a challenge.
#BalancingSelection #FitnessLandscape
#EvolutionarySimulation