RT @sy31802
Co-pathology of #AD and #CTE in a #PART case gave us a chance to capture a mysterious binding site of PET ligand #flortaucipir in #CTE tau fibrils. The second binding type of ligand+amyloids, different from APN1607+#AD tau. Many thanks to @SjorsScheres and @MichelGoed as alwasys. https://twitter.com/SjorsScheres/status/1603705984429555713

Structure of #tau #CTE filaments with @LillyPad PET tracer #flortaucipir. A surprising find, as this compound is used in the clinic for #AD, but we could not see #cryoEM density for the compound on tau #PHFs or #SFs. With @sy31802 & @MichelGoed.
https://www.biorxiv.org/content/10.1101/2022.12.15.520545v1