This study reveals distinct human iTfr & nTfr cell subsets, shedding light on their development, function, and localization. This understanding may lead to targeted therapies to enhance immunity or precisely treat autoimmune diseases. #immunology #FOXP3 #TfrCells

https://www.science.org/doi/10.1126/sciimmunol.ade8162

"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."

#immunology #Treg

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183

#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473