Gene silencing, while highly useful, has limitations in how specific it can work. Meanwhile, DNA enzymes (DNAzymes) are so accurate they can pick out incorrect alleles in RNA sequences.

But the usage of these is curtailed by their low activity due to needing high environmental magnesium.

Now, researchers have developed a targeted DNAzyme without this problem, able to target disease-causing genes.

#DNA #RNA #Medicine #Enzymes #DNAzymes #GeneSilencing #Science #Scicomm

https://www.nature.com/articles/s41467-023-38100-9