@spamless @Medscape

Unfortunately they are yrs away from human trials.

One way to increase ghrelin levels is by drinking carbonated beverages (article title says 'male rats' but they also tested male humans; would be nice to know if true for females) -
https://doi.org/10.1016/j.orcp.2017.02.001

My daughter hates carbonated beverages, tho. I suspect this may have be due to elevated salivary carbonic anhydrase activity.

#ghrelin

Heart failure struggles,
Hunger hormone may improve -
Hopes of better life

#ghrelin #heartfailure #health #haiku #poetry

http://www.medicalnewstoday.com/articles/could-the-hunger-hormone-help-improve-heart-function-in-people-with-heart-failure

@beth_morton

I came across something interesting on carbonated beverages & ghrelin. Ghrelin was found to reduce pain in a migraine model (1). Drinking carbonated beverages increases ghrelin levels after a meal (2). So my preference for soda rather than tea as a caffeine source during migraine might have something to do with this (as opposed just to being cold, which is also helpful).

1- https://doi.org/10.1093/brain/awp265

2- https://doi.org/10.1016/j.orcp.2017.02.001

#ghrelin #migraine

Happy to share our new article, which has been in the making for a veeery long time!

https://insight.jci.org/articles/view/165763

In this study we looked at the control of the entrance of #ghrelin in the #brain

Ghrelin is a #hormone produced by the stomach, which induces hunger. In order to do so, ghrelin needs to enter the brain, to reach neurons in the arcuate nucleus of the #hypothalamus, a region of the brain important for many #endocrine responses.

Here, we explore the role of cells lining the capillaries (such as #perycytes ) at the median eminence, which is on of the "doors" of the brain, where molecules from the periphery are allowed to get in.

We used a mouse model where pericytes can be electrically excited via #optogenetics to study the dynamics of ghrelin entrance in the brain. When we excited pericytes, there was a slow-down of blood flow at the median eminence, resulting in slower entrance of ghrelin, lower and delayed food intake in response to ghrelin injection.

This shows pericytes as a potential therapeutical target for metabolic diseases.

RT @Your_Hormones@twitter.com

How do hormones affect our weight? From #ghrelin to #leptin and puffer fish to Labradors, you can learn more about the topic by listening to our myth-busting podcast Hormones: The Inside Story: https://bit.ly/3v3Kyrs @GilesYeo@twitter.com @EllieRaffan@twitter.com @jlAreta@twitter.com #InsideHormones @Soc_Endo@twitter.com

🐦🔗: https://twitter.com/Your_Hormones/status/1605541094724440070

Warum man umso mehr Nadeln in die Voodoo-Puppe seines Partners oder seiner Partnerin sticht, je größer der #Hunger ist – und warum #Ghrelin uns zum #Gremlin macht …

Henrik Müller erklärt uns die "Psycho-Neuro-Physio-#Biochemie des Hungers": 👉 https://www.laborjournal.de/blog/?p=12742

Can gastrointestinal hormones modulate our reward responses? @cecivez and I ventured into the available data and literature to find that
🎯 ghrelin enhances reward responses within the motivational circuit! w/ @nbkroemer

Find more in our pre-print: https://www.biorxiv.org/content/10.1101/2022.11.30.518539v1

#gutbrainaxis #reward #fMRI #ghrelin #GLP1

#introduction

I am enjoying reading lots of different introductions over the last days so I will hop on the train as well and introduce myself! 👋

I am a PhD student at the #neuroscience for motivation, action, and desire lab working with @nbkroemer 🧠

I am broadly interested in #decisionmaking and in my PhD I am incorporating a metabolic perspective to understand how the #gutbrainaxis influences neural communication, motivation and effort. 🏋️‍♂️

Many psychiatric disorders come along with both motivational and metabolic alterations so the gut-brain perspective might help us to better understand and treat disorders like #depression #anhedonia 🎯

Mostly here for all the diverse science 💡🤩

#fmri #cognitiveneuroscience #dopamine #ghrelin

🎉New preprint together with Uta Sailer, Federica Riva, Jana Lieberz, Dan Campbell-Meiklejohn and Dirk Scheele

... demonstrating that varying #ghrelin concentrations did *not* affect #SocialReward processing 🧠🗣️
#fMRI #compliments

https://www.biorxiv.org/content/10.1101/2022.11.18.516889v1

#? #ghrelin #GH #вещества #h+ @rf
Are there yummy and accessible ghrelin receptor agonists on the market these days?