Trial Underway Testing Engineered Cancer-Killing Viruses

A clinical trial, testing stem cells for neurons fortified with tumor-killing viruses, administered its first doses to a patient with glioma, an aggressive type of brain cancer.

https://sciencebusiness.technewslit.com/?p=45004

#News #Press #Science #Business #Cancer #ClinicalTrial #Gliomas #Glioblastoma #BrainTumor #Biotechnology #Adenovirus #Immunotherapy #Onoclytic #Neurons #StemCells #GrantFunding

Great, up-to-date review of #BrainTumors

"Approximately 49% of malignant brain tumors are #glioblastomas, and 30% are diffusely infiltrating lower-grade #gliomas. Other malignant brain tumors include primary central nervous system (CNS) #lymphoma (7%) and malignant forms of #ependymomas (3%) and #meningiomas (2%)."

https://jamanetwork.com/journals/jama/fullarticle/2801673

Join us Thurs, March 16, at noon CT/1 pm ET as Dr. Mario Suva of Mass General Hospital & Harvard Medical School presents “Dissecting Adult and Pediatric Gliomas by Single-cell Genomics.” He’ll discuss advances in #singlecellgenomics and their application to human adult and pediatric #gliomas, as well as how the studies have helped advance understanding of glioma cell lineages, stem cell programs, immune microenvironment composition and glioma classification. Register. https://bit.ly/SOCC23-MAS

#Yale School of Public Health's Elizabeth Claus, PhD, and colleagues received a $13M grant for their #OPTIMUM study into the molecular #evolution of low-grade #gliomas. Researchers hope extensive genotyping will shed light on optimal treatment. #medmastodon
https://ysph.yale.edu/news-article/yale-biostatistics-researcher-awarded-dollar13-million-grant-to-study-glioma-brain-tumors/

The majority of brain cancers (#gliomas) are very invasive and symptom onset often includes extraordinary changes to behaviors or dramatic side effects like #seizures. Recent studies showed that glioma cells reshape their microenvironment & form #electrically functional pseudo-synapses with neurons to integrate into the brain's #microcircuitry.

So one question naturally arises: What the hell is going on?

Read our latest research pulse blog:
https://www.3brain.com/research-pulse/hijacking-neurons-to-cause-a-seizure

#scicomm #neuroscience

#BrainTumors 🧠

🔸 One source of brain tumors is metastasis -- which are spreads from other tumors, so for instance, lung tumors.

🔸 The brain tumors are a problem because they exist within the cranium, and the cranium is a fixed, bony container. It can't expand. And as a tumor expands, the cranium is not going to expand. It's going to increase the pressure and we're going to have a problem.

🔸 Neurons don't make tumors because they don't divide at all, and they don't get into this uncontrolled division. So what makes tumors? Well, it's other cell types within the brain. And the primary one that does this are #GlialCells.

🔸 Glial cells don't have the limits on division that neurons do. So, glial cells can divide and make these tumors. And so, #gliomas, tumors of glial cells, are the most common type of brain tumor.

🔸 Another type of brain tumor is the type that comes from a division of meningeal cells, and these are called #meningiomas.

🔸 And finally, the other major type of brain tumor is are tumors that come from glandular cells.

🔸 These glandular cells are not neurons. They're gland cells, and they can divide without control. The other gland that we have in our head is called the pituitary, and these pituitary cells can also divide and that's called 'pituitary adenomas'. These #PituitaryAdenoma's are fairly common. They account for about 10 to 25% of inter-cranial tumors.

🖼️ Image source: https://images.app.goo.gl/hfXZKhrd7ahacDsx9