For wealthy and well-insured U.S. patients, exorbitant #prices for #GLP1 meds are no problem. They pay the high price or their gold-plated health insurance takes care of it. But here's a question to ponder. Should #ObesityCare be a #luxury? https://conscienhealth.org/2023/08/high-u-s-drug-prices-high-obesity-rates-twisted-economics/

@leo didn't you say that your daughter told you that you were not to start taking any #GLP1 class drugs because she didn't like that you would have to KEEP taking them for life? You and she may be interested to read this new Wired article. https://www.wired.com/story/ozempic-wegovy-quitting-weight-loss/?bxid=5ee10a3585e9ed3cd5e7047b&cndid=15731479&esrc=AUTO_PRINT&mbid=mbid%3DCRMWIR012019%0A%0A&source=Email_0_EDT_WIR_NEWSLETTER_0_DAILY_ZZ&utm_brand=wired&utm_campaign=aud-dev&utm_content=WIR_Daily_070723&utm_mailing=WIR_Daily_070723&utm_medium=socialshare&utm_source=adreanalangston&utm_term=P4

Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials - PubMed https://pubmed.ncbi.nlm.nih.gov/37024129/?dopt=Abstract https://pubmed.ncbi.nlm.nih.gov/37024129/#msdynttrid=GKdH2JNMPLeiwqSZXvZ0yQiGE4saa-kLWNPxIkBVzZ8 “This study further separates the effect of #diabetes treatments on blood #glucose levels and important outcomes. #SGLT2 inhibitors and #GLP1 receptor agonists reduce all-cause and #cardiovascular mortality, as well as other cardiac-related problems.”

“It’s one thing to reach out to physicians and say ‘We’ve got these treatments and they’re so effective and we want you to know about them,’ I don’t think that’s ever going to explain over 100 meals. You just have to laugh, it’s so crazy.”

by (who else but) @STAT's Nick Florko: https://www.statnews.com/2023/07/05/ozempic-rybelsus-novo-nordisk-meals-for-doctors/

#obesity #drugs #GLP1 #ozempic #wegovy #rybelsus #semaglutide #pharma #BigPharma #health #medicine #healthcare #NovoNordisk

Shortages of #GLP1 medicines are growing worse. Novo Nordisk says "many patients will have difficulty filling #Saxenda prescriptions for the remainder of 2023 and beyond."
Was this foreseeable? Or is #ObesityCare for the few and the wealthy all we get?
https://conscienhealth.org/2023/07/glp-1-medicines-constrained-supply-high-prices-low-access/

This @NewYorker piece by Jia Tolentino, is a MUST-READ if you care about any of the following:
#ScienceJournalism #HealthJournalism #CulturalCriticism
#FatPhobia #FatAcceptance #DietsKill #Feminism #IntersectionalHealth #RacismAndFatphobia
#NovoNordisk #Wegovy #Ozempic #SemaGlutide #GLP1 #SideEffects #WeightCycling
#ThinkOfTheChildren

https://www.newyorker.com/magazine/2023/03/27/will-the-ozempic-era-change-how-we-think-about-being-fat-and-being-thin

GLP-1 agonists
More than just diabetes cure?
Hope to reduce risk

#glp1 #diabetes #cancer #alzheimers #cardiovascular #haiku #poetry

http://www.medicalnewstoday.com/articles/could-glp-1-agonists-be-more-than-just-a-treatment-for-diabetes

My colleagues at WTW have a nice summary of the promise and peril of #GLP1 anti-obesity medications in HR executive:

https://hrexecutive.com/new-anti-obesity-drugs-represent-challenge-opportunity-for-employers/

As I wrote in the Substacks, there's not even a consensus in the medical community on how to define obesity clinically.

https://juliabelluz.substack.com/p/the-long-and-difficult-quest-to-personalize

Still, for many, the effort to tailor treatments in obesity represents a sort of holy grail, even in the context of the #GLP1 revolution and effective drugs such as #ozempic and #wegovy

We just, it seems, aren't quite there yet...

Excited to watch how hundreds of millions of dollars of pharmaceutical company advertising completely shifts public opinion on obesity being "a choice" just so they can market new GLP-1 based weight loss drugs directly to patients. Scientists and doctors spent years trying to advocate for obesity as a chronic biological disease, turns out all they needed was a bigger advertising budget.

/s

https://www.statnews.com/2023/03/05/weight-loss-drugs-changing-obesity-narrative/

#Obesity #Pharma #Drugs #Weight #WeightLoss #GLP1 #Medicine #Science #News #STAT

Dossier der Woche: Abnehmspritze gegen Adipositas. Was bringen Semaglutid und Co gegen das Übergewicht? #Semaglutid #Ozempic #wegovy #Adipositas #Abnehmen #Diabetes #GLP1
https://www.scinexx.de/dossier/abnehmspritze-gegen-adipositas/

But what's lost in the pushback is that the treatment of individuals who presently have obesity must be considered separately from questions about prevention and obesity’s environmental causes.

And right now, the best treatments we have are #bariatricsurgery and #GLP1-based obesity medications such as #ozempic. Even for adolescents.

I wrote how I came around to this view, and why it's less radical than it sounds at a glance
@SubstackInc https://juliabelluz.substack.com/p/what-to-do-about-children-with-obesity

RT @DrDanBrierley@twitter.com

Excited to share our paper showing the anti #obesity drug lorcaserin requires the central #GLP1 system - out now @MolMetab@twitter.com!

Great collab between the Trapp lab @CCMN_London@twitter.com and @LoraHeisler@twitter.com lab @rowett_abdn@twitter.com, with @GilesYeo@twitter.com & colleagues @IMS_MRL@twitter.com

https://www.sciencedirect.com/science/article/pii/S2212877822002344?via%3Dihub#bib20

👇🧵👇

🐦🔗: https://twitter.com/DrDanBrierley/status/1611771979022974976

RT @BevTchangMD
Finally got my hands on a full PDF of the French study on #thyroid #cancer and #GLP1 receptor agonists...

1/

Why prescribe GLP-1 agonists?

For anybody who has an obese patient that's really struggled, look past the idea of them not trying to consider the possibility that there's more to it. And even for doctors who are not obesity specialists and who have not previously prescribed weight loss medications, this is different. This is a new era.

Christine Meyer is an internal medicine physician.

https://youtube.com/shorts/5fZzY_ODz3w

Listen here: https://kevinmd.com/podcast

#diabetes #glp1 #obesity #semaglutide

Who is right for GLP-1 agonists?

I think those patients, those who have been there, did it, tried it, and now are at a point where it's bringing them down and stealing their quality of life and joy that I see an opportunity for these medicines to make a huge difference.

Christine Meyer is an internal medicine physician.

https://youtube.com/shorts/zLE3hMCz6qo

Listen here: https://kevinmd.com/podcast

#diabetes #glp1 #obesity #semaglutide #primarycare

Can gastrointestinal hormones modulate our reward responses? @cecivez and I ventured into the available data and literature to find that
🎯 ghrelin enhances reward responses within the motivational circuit! w/ @nbkroemer

Find more in our pre-print: https://www.biorxiv.org/content/10.1101/2022.11.30.518539v1

#gutbrainaxis #reward #fMRI #ghrelin #GLP1

Introduction: I do many things, but my passion is #flozination & promoting #glp1.