I wonder if there is a link between my childhood epilepsy and the intrusive thoughts that emerged around the same time. Not necessarily in a brain damage sort of way, but in a neurotransmitter kinda way.

#epilepsy #seizures #glutamate #gaba #dangercardio

Little vesicle animation. No receptors yet.

#synapses #glutamate

In case you are in Paris at the end of the month and interested in #synapses, I shall give a talk about tools and methods for #glutamate imaging at the Vision Institute on 30th June. #neuroscience #optobiology

https://www.institut-vision.org/en/our-seminars/815-seeing-glutamate-at-central-synapses.html

@cian I saw that! Thank you! I am glad if that review on #glutamate sensing is useful. As usual, it was a lot of work and nice to know that it's not in vain.

Referenced link: https://medicalxpress.com/news/2023-06-synaptic-vesicles-accumulate-glutamate.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-synaptic-vesicles-accumulate-glutamate.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1666098775600025600#m

RT by @physorg_com: How #synapticvesicles accumulate #glutamate @NatureComms https://www.nature.com/articles/s41467-023-38340-9 https://medicalxpress.com/news/2023-06-synaptic-vesicles-accumulate-glutamate.html

I will have a talk at #NeuroFrance2023 during the S24 session (Thursday May 25th 15:30). If you are interested in #photopharmacology and #glutamate receptors, please come listen to my talk and the other great talks of this session.

#Glutamate dehydrogenase1 supports #HIF1α stability to promote #colorectal #tumorigenesis under #hypoxia

An siRNA screen identifies αKG metabolic enzyme #GDH1 as acetylation-dependent control factor for intestinal cancer progression

https://www.embopress.org/doi/10.15252/embj.2022112675

Intracellular NASPM blocks outward currents in GluA2-lacking AMPA receptors, with no relief at all from a large panel of auxiliary proteins. Important new tool for identifying AMPAR diversity at synapses. We need more ways to peel off the different types! Nice paper from Ian Coombs in the Cull-Candy-Farrant lab at UCL
https://elifesciences.org/articles/66765

#ionchannels #glutamate #synapses #synapticdiversity #electrophysiology

Molecular dynamics simulations of the dimer of AMPA-type glutamate receptor binding domains from DE Shaw and colleagues. Seems to confirm some of our earlier functional work on desensitization (including one of the first mutants we published in 2012!), and also the transient encounters of glutamate on its way to the binding site. 190 µs of simulations!
https://www.sciencedirect.com/science/article/pii/S0969212623000965

#ionchannels #glutamate #MolecularDynamics #electrophysiology #receptors

Quantum mechanics of hydrated calcium in GluA2! Fun Collaboration as part of the #dynion @dfg_public research group.

Mechanism of Calcium Permeation in a #Glutamate Receptor #IonChannel #MolecularDynamics #QMMM

https://pubs.acs.org/doi/10.1021/acs.jcim.2c01494

Vol63 Issue4 #JCIM #compchem
#biophysics

#Glutaminsäure und #Glutamate (E 620–E 625): Gesundheitliche Bewertung der Verwendung als #Lebensmittelzusatzstoffe

➡️ https://www.bfr.bund.de/cm/343/glutaminsaeure-und-glutamate-gesundheitliche-bewertung-der-verwendung-als-lebensmittelzusatzstoffe.pdf

#Glutamat

#Plants #ommunicate #distress using their own kind of #nervoussystem. Model mustard plant uses the same signals as animals to relay distress. Although plant biologists already know that changes to one part of a plant are sensed by the others, they had no idea how that information was transmitted. Now that they have seen the #calcium wave and the role of #glutamate, researchers can better monitor and—perhaps one day even manipulate—the plant's #internalcommunications.https://www.science.org/content/article/plants-communicate-distress-using-their-own-kind-nervous-system

STED #nanoscopy reveals nanoscale rules for #glutamate #receptor organization. Researchers at West Virginia University and Thomas Jefferson University disclosed a robust #synaptic nanoarchitecture of glutamate #receptor #heterotetramers. Read the 📰 in @Nature Communications! @leicamicrosystems

https://www.nature.com/articles/s41467-022-28504-4

interesting article on why (maybe) #jobs that involve intensive thinking make us #tired: https://www.nature.com/articles/d41586-022-02161-5 #sleep #glutamate #work

#dopamine releases #glutamate; dopamine increases arousal/awareness. It makes you focus on and pursue things outside yourself.

"Dopamine is a currency, and it's the way you track pleasure."

The dopamine you have now and the level you had a few minutes ago together determine your subjective drive/enjoyment of life.

* High dopamine: good/driven/interested
* Low dopamine: lethargic/burnt out
* Middle: compare to recent level to determine high/low

#dopamine releases #glutamate; dopamine increases arousal/awareness. It makes you focus on and pursue things outside yourself.

"Dopamine is a currency, and it's the way you track pleasure."

The dopamine you have now and the level you had a few minutes ago together determine your subjective drive/enjoyment of life.

* High dopamine: good/driven/interested
* Low dopamine: lethargic/burnt out
* Middle: compare to recent level to determine high/low

#introduction #TwitterMigration #mastodonmigration

Hi, I am a refugee from Twitter joining the great migration.

Interested in the #science of #life; how the #brain works on a molecular level.
#Synapse #ionchannel #glutamate #electrophysiology #singlemolecule
#parenting #education #mentoring #stem #equity

To make life more beautiful.

Experimental drug shows promise for autism-linked syndromes

https://www.spectrumnews.org/news/experimental-drug-shows-promise-for-autism-linked-syndromes/

#excitatorysignaling #metabolism #glutamate #epilepsy #seizures #autism #News

New resource maps gene expression, regulation in neuron subtypes

https://www.spectrumnews.org/news/toolbox/new-resource-maps-gene-expression-regulation-in-neuron-subtypes/

#excitatorysignaling #inhibitorysignaling #bipolardisorder #geneexpression #schizophrenia #chromatin #glutamate #stemcells #Toolbox #autism #ADHD #GABA #SNPs

New human neuron assays set stage for high-throughput autism drug screens

https://www.spectrumnews.org/news/toolbox/new-human-neuron-assays-set-stage-for-high-throughput-autism-drug-screens/

#treatments #glutamate #stemcells #Toolbox #autism